Note: This document contains side effect information about idelalisib. Some of the dosage forms listed on this page may not apply to the brand name Zydelig.
Common side effects of Zydelig include: hepatotoxicity, pneumonitis, severe colitis, severe diarrhea, exfoliative dermatitis, pneumonia, colitis, abdominal pain, cough, dyspnea, erythematous rash, fever, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, macular eruption, maculopapular rash, nausea, neutropenia, pruritic rash, skin rash, and vomiting. See below for a comprehensive list of adverse effects.
Applies to idelalisib: oral tablet
Oral route (Tablet)
Serious hepatotoxicity, including fatalities, has been reported in 16% to 18% of patients administered idelalisib. Fatal and/or serious diarrhea and colitis has also been reported in 14% to 20% of idelalisib patients. Monitor hepatic function before and during treatment and monitor for the development of diarrhea or colitis. Fatal and/or serious pneumonitis occurred in 4% of idelalisib patients. Monitor for pulmonary symptoms and bilateral interstitial infiltrates. Serious infections, including fatalities, have been reported in 21% to 48% of idelalisib patients. Monitor for signs and symptoms of infection. Fatal and serious intestinal perforation may occur. Interrupt, reduce dose, or discontinue treatment with idelalisib as recommended. Discontinue use if intestinal perforation occurs.
Along with its needed effects, idelalisib (the active ingredient contained in Zydelig) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking idelalisib:
Incidence not known
Some side effects of idelalisib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to idelalisib: oral tablet
The most commonly occurring adverse reactions were pneumonia, pyrexia, sepsis, febrile neutropenia, cough, abdominal pain, chills, rash, fatigue, and diarrhea.
Very common (10% or more): Increased ALT (up to 50%), increased AST (up to 41%), increased GGT (up to 26%)
Very common (10% or more): Diarrhea (up to 47%), nausea (up to 29%), abdominal pain (up to 26%), vomiting (up to 15%)
Common (1% to 10%): Gastroesophageal reflux disease, stomatitis
Very common (10% or more): Cough (up to 29%), pneumonia (up to 25%), dyspnea (up to 17%), upper respiratory tract infection (up to 12%)
Common (1% to 10%): Nasal congestion
Very common (10% or more): Decreased neutrophils (up to 60%), decreased hemoglobin (up to 28%), decreased platelets (up to 26%), increased lymphocytes (up to 25%), decreased lymphocytes (up to 20%)
Very common (10% or more): Hypertriglyceridemia (up to 56%), hyperglycemia (up to 54%), hyponatremia (up to 20%), decreased appetite (up to 16%), hypoglycemia (up to 11%)
Very common (10% or more): Pyrexia (up to 35%), fatigue (up to 30%), chills (up to 21%), asthenia (up to 12%), peripheral edema (up to 10%)
Common (1% to 10%): Pain
Common (1% to 10%): Sepsis, bronchitis, sinusitis, urinary tract infection
Very common (10% or more): Rash (up to 21%), night sweats (up to 12%)
Common (1% to 10%): Arthralgia
Very common (10% or more): Headache (up to 11%)
Very common (10% or more): Insomnia (up to 12%)
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Zydelig