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Zydelig

Generic Name: idelalisib (eye DEL a LIS ib)
Brand Names: Zydelig
Zydelig (idelalisib) is used to treat chronic lymphocytic leukemia, and lymphoma. Includes Zydelig side effects, interactions and indications.
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Drug Information:
Zydelig (idelalisib) is a cancer medication that interferes with the growth and spread of cancer cells in the body. Zydelig is used together with rituximab (Rituxan) to treat chronic lymphocytic leukemia, and certain types of lymphoma. Zydelig is given after other cancer treatments did not work or have stopped working. Zydelig was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed. Learn more

Zydelig Side Effects

Zydelig Side Effects

Note: This document contains side effect information about idelalisib. Some of the dosage forms listed on this page may not apply to the brand name Zydelig.

In Summary

Common side effects of Zydelig include: hepatotoxicity, pneumonitis, severe colitis, severe diarrhea, exfoliative dermatitis, pneumonia, colitis, abdominal pain, cough, dyspnea, erythematous rash, fever, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, macular eruption, maculopapular rash, nausea, neutropenia, pruritic rash, skin rash, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to idelalisib: oral tablet

Warning

Oral route (Tablet)

Serious hepatotoxicity, including fatalities, has been reported in 16% to 18% of patients administered idelalisib. Fatal and/or serious diarrhea and colitis has also been reported in 14% to 20% of idelalisib patients. Monitor hepatic function before and during treatment and monitor for the development of diarrhea or colitis. Fatal and/or serious pneumonitis occurred in 4% of idelalisib patients. Monitor for pulmonary symptoms and bilateral interstitial infiltrates. Serious infections, including fatalities, have been reported in 21% to 48% of idelalisib patients. Monitor for signs and symptoms of infection. Fatal and serious intestinal perforation may occur. Interrupt, reduce dose, or discontinue treatment with idelalisib as recommended. Discontinue use if intestinal perforation occurs.

Along with its needed effects, idelalisib (the active ingredient contained in Zydelig) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking idelalisib:

More common

  • Abdominal or stomach pain or tenderness
  • black, tarry stools
  • body aches or pain
  • chills
  • clay colored stools
  • confusion
  • cough
  • cough producing mucus
  • dark urine
  • decreased appetite
  • difficulty with breathing
  • dizziness
  • ear congestion
  • fainting
  • fast heartbeat
  • fever
  • headache
  • itching or skin rash
  • lightheadedness
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • nausea and vomiting
  • pain
  • pain or tenderness around the eyes and cheekbones
  • painful or difficult urination
  • pale skin
  • rapid, shallow breathing
  • sneezing
  • sore throat
  • stomach cramps
  • stuffy or runny nose
  • swelling of the feet or lower legs
  • tightness in the chest
  • troubled breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watery or bloody diarrhea
  • yellow eyes or skin

Less common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • chest pain
  • cracks in the skin
  • difficulty with swallowing
  • general feeling of discomfort or illness
  • heartburn
  • hives
  • indigestion
  • joint or muscle pain
  • loss of heat from the body
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
  • severe abdominal or stomach pain, cramping, or burning
  • thickening of bronchial secretions
  • vomiting of material that looks like coffee grounds, severe and continuing

Some side effects of idelalisib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • decreased appetite
  • difficulty with moving
  • muscle pain or stiffness
  • night sweats
  • pain in the joints
  • rapid weight gain
  • tingling of the hands or feet
  • trouble sleeping
  • unusual weight gain or loss

For Healthcare Professionals

Applies to idelalisib: oral tablet

General

The most commonly occurring adverse reactions were pneumonia, pyrexia, sepsis, febrile neutropenia, cough, abdominal pain, chills, rash, fatigue, and diarrhea.

Hepatic

Very common (10% or more): Increased ALT (up to 50%), increased AST (up to 41%), increased GGT (up to 26%)

Gastrointestinal

Very common (10% or more): Diarrhea (up to 47%), nausea (up to 29%), abdominal pain (up to 26%), vomiting (up to 15%)

Common (1% to 10%): Gastroesophageal reflux disease, stomatitis

Respiratory

Very common (10% or more): Cough (up to 29%), pneumonia (up to 25%), dyspnea (up to 17%), upper respiratory tract infection (up to 12%)

Common (1% to 10%): Nasal congestion

Hematologic

Very common (10% or more): Decreased neutrophils (up to 60%), decreased hemoglobin (up to 28%), decreased platelets (up to 26%), increased lymphocytes (up to 25%), decreased lymphocytes (up to 20%)

Metabolic

Very common (10% or more): Hypertriglyceridemia (up to 56%), hyperglycemia (up to 54%), hyponatremia (up to 20%), decreased appetite (up to 16%), hypoglycemia (up to 11%)

Other

Very common (10% or more): Pyrexia (up to 35%), fatigue (up to 30%), chills (up to 21%), asthenia (up to 12%), peripheral edema (up to 10%)

Common (1% to 10%): Pain

Immunologic

Common (1% to 10%): Sepsis, bronchitis, sinusitis, urinary tract infection

Dermatologic

Very common (10% or more): Rash (up to 21%), night sweats (up to 12%)

Musculoskeletal

Common (1% to 10%): Arthralgia

Nervous system

Very common (10% or more): Headache (up to 11%)

Psychiatric

Very common (10% or more): Insomnia (up to 12%)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zydelig