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Generic Name: zoster vaccine live (ZOS ter vak SEEN LYV)
Brand Names: Zostavax
Zostavax is used to prevent herpes zoster virus (shingles). Includes Zostavax side effects, interactions and indications.
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Drug Information:
Zostavax (zoster vaccine live) is used to prevent herpes zoster virus (shingles) in people age 50 and older. Herpes zoster is caused by the same virus (varicella) that causes chickenpox in children. When this virus becomes active again in an adult, it can cause herpes zoster, or shingles. Zoster vaccine is a live vaccine that helps prevent shingles. Zostavax works by exposing you to a small dose of live virus, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body. Learn more

Zostavax Side Effects

Zostavax Side Effects

Note: This document contains side effect information about zoster vaccine live. Some of the dosage forms listed on this page may not apply to the brand name Zostavax.

For the Consumer

Applies to zoster vaccine live: subcutaneous powder for suspension

Along with its needed effects, zoster vaccine live (the active ingredient contained in Zostavax) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zoster vaccine live:

Less common

  • Collection of blood under the skin, a deep, dark purple bruise, itching, pain, redness, swelling, or a hard lump at the injection site

Incidence not known

  • Blurred vision
  • change in color vision
  • cough
  • difficulty seeing at night
  • difficulty swallowing
  • dizziness
  • eye redness
  • fast heartbeat
  • fever
  • hives, itching, skin rash
  • increased sensitivity of the eyes to sunlight
  • pain around the eyes
  • painful blisters on the trunk of the body
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • temporary swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest
  • unusual tiredness or weakness
  • vision loss

Some side effects of zoster vaccine live may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Headache

Incidence not known

  • Difficulty in moving
  • joint pain or swelling
  • muscle ache, cramp, pain, or stiffness
  • nausea

For Healthcare Professionals

Applies to zoster vaccine live: subcutaneous powder for injection


The most common adverse events were headache and injection site reactions.


Very common (10% or more): Injection site pain (up to 53.9%), injection site erythema (48.1%), injection site swelling (40.4%), pruritus (11.3%)

Common (1% to 10%): Warmth, hematoma, induration

Postmarketing reports: Injection site rash, injection site urticaria, transient injection site lymphadenopathy

Nervous system

Common (1% to 10%): Headache, asthenia


Common (1% to 10%): Death, fever, asthenia

The most common reported cause of death was cardiovascular disease (10 in the vaccine group, 8 in the placebo group). The overall incidence of death occurring at any time during the study was similar between groups: 793 deaths (4.1%) in the vaccine group and 795 deaths (4.1%) in the placebo group.


Common (1% to 10%): Congestive heart failure or pulmonary edema

Congestive heart failure or pulmonary edema occurred in 1.5% of patients receiving the vaccine versus 1.2% of patients receiving placebo in the AE monitoring substudy.


Common (1% to 10%): Respiratory infection, flu syndrome, rhinitis, respiratory disorder

Very rare (less than 0.01%): Asthma exacerbation


Common (1% to 10%): Diarrhea

Postmarketing reports: Nausea


Common (1% to 10%): Skin disorder

Rare (less than 0.1%): Non-injection site varicella-type rash, non-injection site zoster-like rash

Postmarketing reports: Rash


Common (1% to 10%): Pain in extremity

Very rare (less than 0.01%): Polymyalgia rheumatica

Postmarketing reports: Arthralgia, myalgia


Very rare (less than 0.01%): Anaphylactic reaction

Postmarketing reports: Hypersensitivity reactions including anaphylactic reactions


Very rare (less than 0.01%): Varicella

Postmarketing reports: Herpes zoster (vaccine strain)


Frequency not reported: Lymphadenopathy


Postmarketing reports: Necrotizing retinitis (patients on immunosuppressive therapy)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zostavax