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Generic Name: vorapaxar (VOR a PAX ar)
Brand Names: Zontivity
Zontivity (vorapaxar) is used for the prevention of cardiovascular events. Includes Zontivity side effects, interactions and indications.
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Drug Information:
Zontivity (vorapaxar) helps to prevent platelets in your blood from sticking together and forming a blood clot. An unwanted blood clot can occur with certain heart or blood vessel conditions. Zontivity is used to lower the risk of stroke or serious heart problems in people who have had a heart attack or a blood vessel disorder affecting circulation in the arms and legs. Zontivity is sometimes used together with aspirin or clopidogrel (Plavix). You should not use Zontivity if you have active bleeding, stomach or intestinal bleeding, a head injury, or if you have a history of stroke (including "mini-stroke"), bleeding in your brain, or increased pressure inside the skull. Learn more

Zontivity Side Effects

Zontivity Side Effects

Note: This document contains side effect information about vorapaxar. Some of the dosage forms listed on this page may not apply to the brand name Zontivity.

In Summary

Common side effects of Zontivity include: hemorrhage. Other side effects include: anemia and gastrointestinal hemorrhage. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vorapaxar: oral tablet


Oral route (Tablet)

Antiplatelet agents increase the risk of bleeding, including intracranial hemorrhage (ICH) and fatal bleeding. Do not use vorapaxar in patients with active pathological bleeding or a history of stroke, TIA, or ICH.

Along with its needed effects, vorapaxar (the active ingredient contained in Zontivity) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vorapaxar:

Less common

  • Bloody or black, tarry stools
  • constipation
  • pale skin
  • severe stomach pain
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds


  • Confusion
  • headache, sudden and severe
  • nausea and vomiting
  • weakness

Some side effects of vorapaxar may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • rashes
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to vorapaxar: oral tablet


Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.


Very common (10% or more): Bleeding

Common (1% to 10%): Anemia, iron deficiency


Common (1% to 10%): Rashes, eruptions, exanthemas


Common (1% to 10%): Gastrointestinal bleeding


Common (1% to 10%): Retinopathy or retinal disorder, diplopia/oculomotor disturbances

Nervous system

Uncommon (0.1% to 1%): Intracranial bleeding

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zontivity