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Zonegran

Generic Name: zonisamide (zoe NIS a mide)
Brand Names: Zonegran
Zonegran (zonisamide) is used to treat partial seizures in adults with epilepsy. Includes Zonegran side effects, interactions and indications.
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Drug Information:
Zonegran (zonisamide) is a sulfa drug with anti-convulsant effects. Zonegran is used together with other anti-convulsant medications to treat partial seizures in adults with epilepsy. Zonegran may also be used for purposes not listed in this medication guide. You should not use Zonegran if you are allergic to zonisamide, or to other sulfa drugs such as sulfamethoxazole (Gantanol), sulfisoxazole (Gantrisin), or sulfamethoxazole-trimethoprim (Bactrim, Septra, Sulfatrim, SMX-TMP, and others). A sulfa drug allergic reaction can be fatal. Learn more

Zonegran Side Effects

Zonegran Side Effects

Note: This document contains side effect information about zonisamide. Some of the dosage forms listed on this page may not apply to the brand name Zonegran.

For the Consumer

Applies to zonisamide: oral capsule

Along with its needed effects, zonisamide (the active ingredient contained in Zonegran) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zonisamide:

More common

  • Discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • mood or mental changes
  • shakiness or unsteady walking
  • tiredness
  • trouble with concentrating
  • trouble with sleeping

Less common

  • Agitation
  • bruising
  • delusions
  • hallucinations
  • large, flat blue or purplish patches on the skin
  • rash

Some side effects of zonisamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • anxiety
  • difficulty with memory
  • dizziness
  • double vision
  • headache
  • loss of appetite
  • nausea
  • restlessness
  • sleepiness
  • unusual drowsiness
  • unusual tiredness or weakness

Less common

  • Aching muscles or joints
  • acid or sour stomach
  • bad, unusual, or unpleasant taste in the mouth
  • belching
  • change in taste
  • chills
  • constipation
  • diarrhea
  • difficulty with speaking
  • difficulty with thinking
  • dry mouth
  • fever
  • general ill feeling
  • headache
  • heartburn
  • indigestion
  • mental slowness
  • nervousness
  • runny or stuffy nose
  • sneezing
  • tingling, burning, or prickly feelings on the skin
  • uncontrolled, back and forth, or rolling eye movements
  • weight loss

For Healthcare Professionals

Applies to zonisamide: oral capsule

General

The most common adverse reactions to this drug are somnolence, dizziness, and anorexia.

Gastrointestinal

Very common (10% or more): Anorexia (13%)

Common (1% to 10%): Abdominal pain, nausea, diarrhea, dyspepsia, constipation, dry mouth

Nervous system

Very common (10% or more): Somnolence (17%), dizziness (13%), headache (10%), ataxia

Common (1% to 10%): Paresthesia, fatigue, tiredness, bradyphrenia, tremor

Uncommon (0.1% to 1%): Convulsion

Very rare (less than 0.01%): Coma, grand mal seizure, myasthenic syndrome, neuroleptic malignant syndrome, status epilepticus

Postmarketing reports: Restless legs syndrome

Other

Common (1% to 10%): Speech abnormalities, difficulties in verbal expression, taste perversion

Psychiatric

Very common (10% or more): Agitation, irritability, confusional state, depression

Common (1% to 10%): Difficulty concentrating, difficulty with memory, mental slowing, insomnia, anxiety, nervousness, affect liability, psychotic disorder

Uncommon (0.1% to 1%): Anger, aggression, suicidal ideation, suicide attempt

Very rare (less than 0.01%): Hallucination, amnesia, mania

Ocular

Common (1% to 10%): Nystagmus, diplopia

Dermatologic

Common (1% to 10%): Rash

Very rare (less than 0.01%): Drug rash with eosinophilia and systemic symptoms, anhidrosis, erythema multiforme, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis

Metabolic

Very common (10% or more): Anorexia

Common (1% to 10%): Weight loss

Very rare (less than 0.01%): Metabolic acidosis

Postmarketing reports: Elevated creatine phosphokinase

Hematologic

Common (1% to 10%): Ecchymosis

Very rare (less than 0.01%): Agranulocytosis, aplastic anemia, leukocytosis, leucopenia, lymphadenopathy, pancytopenia, thrombocytopenia

Respiratory

Common (1% to 10%): Rhinitis

Uncommon (0.1% to 1%): Pneumonia

Endocrine

Uncommon (0.1% to 1%): Urinary tract infection

Postmarketing reports: Acute pancreatitis

Musculoskeletal

Postmarketing reports: Rhabdomyolysis

Genitourinary

Uncommon (0.1% to 1%): Urinary tract infection

Hypersensitivity

Common (1% to 10%): Hypersensitivity

Very rare (less than 0.01%): Drug induced hypersensitivity syndrome

Immunologic

Common (1% to 10%): Influenza syndrome

Renal

Very rare (less than 0.01%): Renal tubular acidosis

Frequency not reported: Nephrolithiasis, hydronephrosis, renal failure, urine abnormality

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zonegran