Commonly reported side effects of zolmitriptan include: dysgeusia. Other side effects include: dizziness, drowsiness, hyperesthesia, jaw pain, nausea, neck pain, paresthesia, sore throat, flushing sensation, local pain, and sensation of cold. See below for a comprehensive list of adverse effects.
Applies to zolmitriptan: oral tablet, oral tablet disintegrating
Other dosage forms:
Along with its needed effects, zolmitriptan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking zolmitriptan:
Less common or rare
Incidence not known
Some side effects of zolmitriptan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to zolmitriptan: nasal spray, oral tablet, oral tablet disintegrating
Common (1% to 10%): Chest pain/tightness/pressure and/or heaviness, neck/throat/jaw pain/tightness/pressure, palpitations
Uncommon (0.1% to 1%): Arrhythmias, hypertension, syncope, tachycardia
Rare (less than 0.1%): Angina pectoris, myocardial infarct, coronary vasospasm, QT prolongation, thrombophlebitis
Rare reports of serious cardiac adverse events have been reported including acute myocardial infarction within a few hours following administration of this drug.
Chest pain/tightness/pressure and/or heaviness appear to be dose-related occurring in 2%, 3%, and 4% of patients receiving 1 mg, 2.5 mg, and 5 mg, respectively. Neck/throat/jaw pain/tightness/pressure occurred in 4%, 7%, and 10% of patients, respectively.
Very Common (greater than 10%): Taste disturbances (up to 21%, inhaler)
Common (1% to 10%): Paresthesia, somnolence, dizziness, hyperesthesia
Rare (less than 0.1%): Cerebral ischemia, amnesia, convulsions, ataxia, dystonia, hyperkinesia, hypotonia, hypertonia
Frequency not reported: Serotonin syndrome
Paresthesia appears to be a dose-related adverse event occurring in 5%, 7%, and 9% of patients receiving 1 mg, 2.5 mg, and 5 mg, respectively.
Common (1% to 10%): Warm/cold sensation, heaviness other than chest or neck, pressure/tightness/heaviness, vertigo, asthenia, chills
Uncommon (0.1% to 1%): Tinnitus, hyperacusis, ear pain
Common (1% to 10%): Nausea, dry mouth, dysphagia, dyspepsia, abdominal pain, vomiting
Uncommon (0.1% to 1%): Gastroenteritis, increased thirst
Rare (less than 0.1%): Stomatitis, constipation, hematemesis, pancreatitis, melena, ulcer
Very rare (less than 0.01%): Bloody diarrhea, gastrointestinal infarction or necrosis, gastrointestinal ischemic events, ischemic colitis, splenic infarction
The most common adverse reactions included neck, throat, jaw pain; dizziness; paresthesia; asthenia; somnolence; warm and cold sensation; nausea; heaviness sensation; and dry mouth. In adolescents treated with the nasal spray, the more commonly reported adverse reactions included dysgeusia, nasal discomfort, dizziness, oropharyngeal pain, and nausea.
Uncommon (0.1% to 1%): ecchymosis
Rare (less than 0.1%): Thrombocytopenia, eosinophilia, leucopenia
Uncommon (0.1% to 1%): Increased appetite, thirst
Rare (less than 0.1%): Anorexia, hyperglycemia
Common (1% to 10%): Arthralgia, myalgia, muscle weakness
Uncommon (0.1% to 1%): Back pain, leg cramps, tenosynovitis
Rare (less than 0.1%): Arthritis, tetanus, twitching
Common (1% to 10%): Disorder/discomfort of nasal cavity, throat pain, throat tightness, oropharyngeal pain
Uncommon (0.1% to 1%): Pharyngitis, rhinitis, dyspnea, sinusitis, bronchitis, increased cough, epistaxis, laryngeal edema, hiccup, laryngitis, yawn
Rare (less than 0.1%): Apnea, voice alteration
Uncommon (0.1% to 1%): Allergic reactions
Postmarketing reports: Hypersensitivity reactions including angioedema, anaphylactic reactions and anaphylactic shock
Rare (less than 0.1%): Diplopia, dry eyes, lacrimation, conjunctivitis, eye pain, visual field defect
Uncommon (0.1% to 1%): Polyuria, urinary urgency, cystitis, hematuria
Rare (less than 0.1%): Urinary frequency, miscarriage, dysmenorrhea
Common (1% to 10%): Sweating, facial edema
Uncommon (0.1% to 1%): Urticaria, pruritus, rash, photosensitivity reaction
Rare (less than 0.1%): Angioedema
Common (1% to 10%): Local irritation or soreness at the site of administration of nasal spray
In clinical trials using the nasal spray approximately 3% (n=460) patients reported local irritation or soreness at the site of administration. Effects were severe in about 1% of patients and approximately 57% resolved in 1 hour. Nasopharyngeal examinations of a subset of patients failed to demonstrate any clinically significant changes with repeated use of the nasal spray.
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Zolmitriptan