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Generic Name: vorinostat (vor IN o stat)
Brand Names: Zolinza
Zolinza is used to treat skin problems caused by cutaneous T-cell lymphoma. Learn about side effects, interactions and indications.
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Drug Information:
Zolinza (vorinostat) is a prescription medicine used to treat skin problems caused by cutaneous T-cell lymphoma. Zolinza is usually given after other treatments did not work or have stopped working, or your cutaneous T-cell lymphoma gets worse or comes back after you have taken other medicines. It is not known if Zolinza is safe and effective in children. You should not use Zolinza if you are allergic to vorinostat, or if you have severe liver disease. Do not use Zolinza if you are pregnant. It could harm the unborn baby. Learn more

Zolinza Side Effects

Zolinza Side Effects

Note: This document contains side effect information about vorinostat. Some of the dosage forms listed on this page may not apply to the brand name Zolinza.

In Summary

Common side effects of Zolinza include: anemia, diarrhea, nausea, thrombocytopenia, and vomiting. Other side effects include: pulmonary embolism. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vorinostat: oral capsule

Along with its needed effects, vorinostat (the active ingredient contained in Zolinza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vorinostat:

More common

  • Anxiety
  • black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • body aches or pain
  • chest pain
  • chills
  • confusion
  • convulsions
  • cough
  • decreased urine
  • diarrhea
  • dizziness or lightheadedness
  • dry mouth
  • ear congestion
  • fainting
  • fast heartbeat
  • fever
  • headache
  • increased thirst
  • irregular heartbeat
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nasal congestion
  • nausea or vomiting
  • no blood pressure
  • no breathing
  • no pulse
  • numbness or tingling in the face, arms, or legs
  • numbness or tingling in the hands, feet, or lips
  • pain, redness, or swelling in the arm or leg
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • runny nose
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden shortness of breath or troubled breathing
  • swollen glands
  • trouble speaking, thinking, or walking
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual drowsiness, dullness, or feeling of sluggishness
  • unusual tiredness or weakness

Less common

  • Persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • white, yellow, or waxy scar-like area


  • Chest discomfort
  • general feeling of illness
  • hoarseness
  • indigestion
  • pain or discomfort in the arms, jaw, back, or neck
  • rapid, shallow breathing
  • severe nausea or vomiting
  • sneezing
  • stomach pain
  • sweating
  • tightness in the chest
  • vomiting of blood or material that looks like coffee grounds
  • wheezing
  • yellow skin and eyes

Some side effects of vorinostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change in taste
  • cracks in the skin
  • difficulty having a bowel movement (stool)
  • hair loss or thinning of the hair
  • itching skin
  • lack or loss of strength
  • loss of heat from the body
  • loss of taste
  • muscle spasm
  • red, swollen skin
  • scaly skin

For Healthcare Professionals

Applies to vorinostat: oral capsule


Very common (10% or more): Diarrhea (45%), nausea (37%), dry mouth (16%), vomiting (12%), constipation (11%)


Very common (10% or more): Thrombocytopenia (26%), anemia (13%)

Frequency not reported: Thromboembolism, deep vein thrombosis


Very common (10% or more): Alopecia (16%), pruritus (12%)

Nervous system

Very common (10% or more): Dysgeusia (23%), chills (11%), headache (10%)


Very common (10% or more): Cough (11%), upper respiratory infection (11%)

Common (1% to 10%): Pulmonary embolism


Very common (10% or more): Fatigue (45%), pyrexia (11%)


Very common (10% or more): Anorexia (23%), weight loss (20%), muscle spasms (15%), blood creatinine increased (12%), peripheral edema (13%)

Common (1% to 10%): Hyperglycemia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zolinza