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Generic Name: clindamycin and tretinoin (topical) (klin da MYE sin and TRET i noyn TOP i kal)
Brand Names: Veltin, Ziana
Ziana (clindamycin and tretinoin) is used to treat severe nodular acne in adults and children who are at least 12 years old. Includes Ziana side effects, interactions and indications.
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Drug Information:
Ziana is a gel containing a combination of clindamycin and tretinoin. Clindamycin is an antibiotic. It fights bacteria in the body. Tretinoin is a form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. Ziana is used to treat severe nodular acne in adults and children who are at least 12 years old. Ziana may also be used for purposes other than those listed in this medication guide. Avoid getting Ziana in your eyes, mouth, or nose (or in the creases of your nose), or on your lips. If it does get into any of these areas, wash with water. Do not apply Ziana to sunburned, windburned, dry, chapped, irritated, or broken skin. Learn more

Ziana Side Effects

Ziana Side Effects

Note: This document contains side effect information about clindamycin / tretinoin topical. Some of the dosage forms listed on this page may not apply to the brand name Ziana.

For the Consumer

Applies to clindamycin/tretinoin topical: topical application gel/jelly

Along with its needed effects, clindamycin/tretinoin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking clindamycin/tretinoin topical:

More common

  • Dryness and peeling of the skin
  • flushing or redness of the skin
  • itching
  • unusually warm skin

Less common

  • Burning or stinging at the site of application
  • changes in the color of the skin
  • fever
  • stomach cramps, tenderness, or pain
  • watery or bloody diarrhea

Some side effects of clindamycin / tretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Cough
  • dry skin
  • headaches
  • muscle aches
  • pain and tenderness around the eyes and cheekbones
  • shortness of breath or troubled breathing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest or wheezing
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clindamycin / tretinoin topical: topical gel


The most commonly reported side effects were erythema, dryness, and itching.


Very common (10% or more): Erythema, dryness

Common (1% to 10%): Sunburn, scaling, burning, itching

Uncommon (0.1% to 1%): Acne, dry skin, seborrhea, photosensitivity reaction, pruritus, rash, exfoliative rash, skin exfoliation

Rare (less than 0.1%): Dermatitis, herpes simplex, rash macular, skin bleeding, skin depigmentation, skin irritation


Common (1% to 10%): Application site dryness, application site irritation, application site exfoliation, application site erythema, application site pruritus, application site dermatitis

Uncommon (0.1% to 1%): Application site reaction, application site burning

Rare (less than 0.1%): Application site swelling, application site erosion, application site discoloration, application site desquamation


Rare (less than 0.1%): Feeling hot, pain


Rare (less than 0.1%): Hypothyroidism


Rare (less than 0.1%): Gastroenteritis, nausea


Rare (less than 0.1%): Hypersensitivity

Nervous system

Rare (less than 0.1%): Headache


Rare (less than 0.1%): Eye irritation

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Ziana