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Generic Name: ziv-aflibercept (ZIV a FLIB er sept)
Brand Names: Zaltrap
Zaltrap (aflibercept) is used in combination with other medications to treat colorectal cancer. Includes Zaltrap side effects, interactions and indications.
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Drug Information:
Zaltrap (ziv-aflibercept) is made from a human antibody fragment. It works by keeping new blood vessels from forming in a fast-growing tumor. Zaltrap is used in combination with other medications to treat colorectal cancer. Zaltrap is usually given after other medications have been tried without successful treatment. You should not use Zaltrap if you have severe bleeding or uncontrolled hypertension (high blood pressure). Before you receive Zaltrap, tell your doctor if you have high blood pressure, open sores or skin wounds, or if you have had surgery or dental work within the past 4 weeks. Learn more

Zaltrap Side Effects

Zaltrap Side Effects

Note: This document contains side effect information about ziv-aflibercept. Some of the dosage forms listed on this page may not apply to the brand name Zaltrap.

For the Consumer

Applies to ziv-aflibercept: intravenous solution


Intravenous route (Solution)

Severe and sometimes fatal hemorrhage, including gastrointestinal hemorrhage, has been reported. Monitor for signs and symptoms of bleeding and do not administer in patients with severe hemorrhage. Gastrointestinal (GI) perforation including fatalities may occur. Discontinue if GI perforation occurs. Severely compromised wound healing may occur. Suspend therapy for at least 4 weeks prior to elective surgery, and do not resume for at least 4 weeks following major surgery and until the surgical wound is fully healed.

Along with its needed effects, ziv-aflibercept (the active ingredient contained in Zaltrap) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ziv-aflibercept:

More common

  • Anxiety
  • black, tarry stools
  • bladder pain
  • bleeding gums
  • blood in the urine or stools
  • bloody nose
  • blurred vision
  • chest pain
  • confusion
  • cough or hoarseness
  • decreased urination
  • difficult, burning, or painful urination
  • dizziness or lightheadedness
  • dry mouth
  • excessive thirst
  • fainting
  • fever or chills
  • frequent urge to urinate
  • headache
  • hoarseness
  • lower back or side pain
  • nervousness
  • pain or swelling around the rectum
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • slow or fast heartbeat
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden shortness of breath or troubled breathing
  • sunken eyes
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • voice changes
  • wrinkled skin

Some side effects of ziv-aflibercept may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abdominal or stomach pain
  • decreased appetite
  • diarrhea
  • lack or loss of strength
  • redness, swelling, or pain of the skin
  • runny nose
  • scaling of the skin on the hands and feet
  • swelling or inflammation of the mouth
  • tingling of the hands and feet
  • ulceration of the skin

For Healthcare Professionals

Applies to ziv-aflibercept: intravenous solution


Very common (10% or more): Hypertension (41%)

Common (1% to 10%): Arterial thromboembolic events (ATE) (e.g., transient ischemic attack, cerebrovascular accident, angina pectoris)

Postmarketing reports: Cardiac failure, ejection fraction decreased


Very common (10% or more): Palmar-plantar erythrodysesthesia syndrome (11%)

Common (1% to 10%): Skin hyperpigmentation


Very common (10% or more): Diarrhea (69%), stomatitis (50%), abdominal pain (27%), abdominal pain upper (11%)

Common (1% to 10%): Fistulas (anal, enterovesical, enterocutaneous, colovaginal, intestinal sites), dehydration, oropharyngeal pain, hemorrhoids, rectal hemorrhage, proctalgia

Uncommon (0.1% to 1%): GI hemorrhage, toothache


Common (1% to 10%): Urinary tract infection


Very common (10% or more): Leukopenia (78%), neutropenia (67%), thrombocytopenia (35%), hemorrhage (38%)


Uncommon (0.1% to 1%): Hypersensitivity


Very common (10% or more): Infections (46%)

Common (1% to 10%): Immunogenicity


Very common (10% or more): Anorexia (32%), weight loss (32%)

Postmarketing reports: Osteonecrosis of the jaw

Nervous system

Very common (10% or more): Headache (22%)

Uncommon (0.1% to 1%): Reversible posterior leukoencephalopathy syndrome (RPLS)


Very common (10% or more): Fatigue (48%), dysphonia (25%), asthenia (18%)

Uncommon (0.1% to 1%): Compromised wound healing


Very common (10% or more): Proteinuria (62%), serum creatinine increased (23%)


Very common (10% or more): Epistaxis (28%), dyspnea (12%)

Common (1% to 10%): Rhinorrhea, nasopharyngitis


Very common (10% or more): AST increased (62%), ALT increased (50%)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zaltrap