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Generic Name: ketotifen ophthalmic (kee toe TYE fen off THAL mik)
Brand Name: Alaway, Claritin Eye, Refresh Eye Itch Relief, Zaditor
Physician reviewed Zaditor patient information - includes Zaditor description, dosage and directions.
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Drug Information:
Ketotifen is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Zaditor (for use in the eyes) is used to treat itching of the eyes caused by allergy to dust, pollen, animals, or other allergens. Zaditor may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Learn more

Zaditor Side Effects

Zaditor Side Effects

Note: This document contains side effect information about ketotifen ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Zaditor.

In Summary

Common side effects of Zaditor include: conjunctival injection, headache, and rhinitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ketotifen ophthalmic: ophthalmic solution

Along with its needed effects, ketotifen ophthalmic (the active ingredient contained in Zaditor) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking ketotifen ophthalmic:

More common

  • Eye redness and swelling

Less common

  • Eye discharge
  • eye discomfort
  • eye pain
  • hives
  • increased itching of eyes
  • rash.

Some side effects of ketotifen ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headaches
  • stuffy or runny nose

Less common

  • Burning or stinging of eyes
  • dry eyes
  • eyelid disorder
  • eye sensitivity to light
  • fever, tiredness, achiness, and sore throat
  • increase in size of pupils
  • sore throat
  • tearing.

For Healthcare Professionals

Applies to ketotifen ophthalmic: ophthalmic solution


Common (1% to 10%): Irritation, pain, punctate keratitis, punctate corneal epithelial erosion

Uncommon (0.1% to 1%): Blurred vision, dry eye, eyelid disorder, conjunctivitis, photophobia, conjunctival hemorrhage

Postmarketing reports: Swelling, eyelid pruritus, edema

Ketotifen instillation was associated with mild to moderate burning or stinging in 98% of patients (n=35) in one trial.

Nervous system

Uncommon (0.1% to 1%): Headache, somnolence

Postmarketing reports: Dizziness


Postmarketing reports: Exacerbation of asthma


The most commonly reported adverse effects have included eye irritation, eye pain, punctate keratitis, and punctate corneal epithelial erosion.


Uncommon (0.1% to 1%): Rash, eczema, urticaria

Postmarketing reports: Contact dermatitis, facial edema, exacerbation of eczema


Uncommon (0.1% to 1%): Dry mouth


Uncommon (0.1% to 1%): Hypersensitivity, allergic reactions

Postmarketing reports: Exacerbation of preexisting allergic conditions

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Zaditor