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Generic Name: lifitegrast ophthalmic (LIF e TEG rast off THAL mik)
Brand Names: Xiidra
Xiidra (lifitegrast) is used to treat dry eye disease. Includes Xiidra side effects, interactions and indications.
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Drug Information:
Xiidra (lifitegrast) works by blocking a certain protein on the surface of cells in your body. This protein can cause your eyes to not produce enough tears, or to produce tears that are not the correct consistency to keep your eyes healthy. Xiidra eye drops are used to treat symptoms of dry eye disease. Xiidra may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Learn more

Xiidra Side Effects

Xiidra Side Effects

Note: This document contains side effect information about lifitegrast ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Xiidra.

For the Consumer

Applies to lifitegrast ophthalmic: ophthalmic solution

Along with its needed effects, lifitegrast ophthalmic (the active ingredient contained in Xiidra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lifitegrast ophthalmic:

More common

  • Changes in vision
  • eye irritation or discomfort

Less common

  • Blurred vision
  • redness of the white part of the eyes or inside of the eyelids

Some side effects of lifitegrast ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change in taste
  • loss of taste

Less common

  • Cough
  • discomfort or itching of the eyes
  • drainage from the eyes
  • fever
  • headache
  • pain or tenderness around the eyes and cheekbones
  • stuffy or runny nose
  • tightness of the chest
  • troubled breathing
  • watering of the eyes

For Healthcare Professionals

Applies to lifitegrast ophthalmic: ophthalmic solution


The most commonly reported side effects included instillation site irritation, dysgeusia, and reduced visual acuity.


Common (1% to 10%): Increased lacrimation, reduced visual acuity, blurred vision, conjunctival hyperemia, eye irritation, eye discharge/pruritus/discomfort

Nervous system

Common (1% to 10%): Dysgeusia, headache


Common (1% to 10%): Instillation site irritation


Common (1% to 10%): Sinusitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Xiidra