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Generic Name: fluticasone nasal (floo TIK a sone)
Brand Names: Xhance
Xhance Nasal Spray (fluticasone) is used to treat nasal polyps in adults. Includes Xhance side effects, interactions and indications.
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Drug Information:
Xhance is a nasal spray containing fluticasone propionate. Fluticasone propionate is a corticosteroid that prevents the release of substances in the body that cause inflammation. Xhance nasal spray is a prescription medicine used to treat nasal polyps in adults. It is not known if Xhance is safe and effective in children. Before using Xhance Nasal Spray, tell your doctor if you have glaucoma or cataracts, liver disease, diabetes, herpes simplex virus of your eyes, tuberculosis or any other infection, sores or ulcers inside your nose, or if you have recently had injury of or surgery on your nose. Learn more

Xhance Side Effects

Fluticasone nasal Side Effects

In Summary

Commonly reported side effects of fluticasone nasal include: epistaxis. Other side effects include: asthma, fever, nausea, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to fluticasone nasal: nasal spray

Along with its needed effects, fluticasone nasal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluticasone nasal:

More common

  • Bloody nose
  • cough
  • fever
  • headache
  • muscle aches
  • pain or tenderness around the eyes and cheekbones
  • sore throat
  • stuffy or runny nose
  • tightness of the chest
  • troubled breathing
  • unusual tiredness or weakness

Less common

  • Blurred vision
  • change in vision
  • loss of vision

Incidence not known

  • Difficulty with swallowing
  • dizziness
  • fast heartbeat
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • skin rash, itching, hives or welts

Some side effects of fluticasone nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Back pain
  • dizziness
  • pain in the mouth and nose
  • stomach discomfort
  • toothache
  • weight increased

For Healthcare Professionals

Applies to fluticasone nasal: nasal spray


Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis effects (including growth reduction)

Nervous system

Common (1% to 10%): Headache, unpleasant taste, unpleasant smell


Common (1% to 10%): Toothache, nausea, diarrhea, abdominal distension, vomiting, gastrointestinal gaseous symptoms

Frequency not reported: Gum signs and symptoms


Very rare (less than 0.01%): Hypersensitivity reactions (including anaphylaxis, angioedema, rash, urticaria, bronchospasm)


Common (1% to 10%): Conjunctivitis

Very rare (less than 0.01%): Cataracts, glaucoma, raised intraocular pressure

Frequency not reported: Transient ocular changes


Frequency not reported: Candida albicans infection, immunosuppression


Very common (10% or more): Nasopharyngitis (26%), epistaxis (20%)

Common (1% to 10%): Pharyngolaryngeal pain, nasal ulceration, cough, pharyngitis, bronchitis, nasal dryness, throat irritation, throat dryness, blood in nasal mucosa, nasal irritation

Uncommon (0.1% to 1%): Rhinalgia, nasal discomfort (including nasal burning, nasal soreness)

Postmarketing reports: Nasal septal perforation


The most commonly reported side effects were nasopharyngitis, epistaxis, and pyrexia.


Common (1% to 10%): Back pain


Very common (10% or more): Pyrexia

Frequency not reported: Impaired wound healing

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Xhance