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Generic Name: velaglucerase alfa (VEL a GLOO ser ase AL fa)
Brand Names: VPRIV
VPRIV (velaglucerase alfa) is used as an enzyme replacement in people with Type I Gaucher disease. Includes VPRIV side effects, interactions and indications.
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Drug Information:
VPRIV (velaglucerase alfa) is a man-made form of an enzyme that occurs naturally in the body. It is used as an enzyme replacement in people with Type I Gaucher disease. Gaucher disease is a genetic condition in which the body lacks the enzyme needed to break down certain fatty materials (lipids). Lipids can build up in the body, causing symptoms such as easy bruising or bleeding, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones that are easily fractured. VPRIV may improve the condition of the liver, spleen, bones, and blood cells in people with Type I Gaucher disease, however, VPRIV is not a cure for this condition. Learn more

Vpriv Side Effects

VPRIV Side Effects

Note: This document contains side effect information about velaglucerase alfa. Some of the dosage forms listed on this page may not apply to the brand name VPRIV.

For the Consumer

Applies to velaglucerase alfa: intravenous powder for solution

Along with its needed effects, velaglucerase alfa (the active ingredient contained in VPRIV) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking velaglucerase alfa:

More common

  • Body aches or pain
  • cough
  • difficulty with breathing
  • dizziness
  • ear congestion
  • facial swelling
  • fever or chills
  • headache
  • loss of voice
  • nasal congestion
  • nausea or vomiting
  • runny nose
  • shortness of breath
  • skin rash
  • sneezing
  • sore throat
  • unusual tiredness or weakness

Less common

  • Blurred vision
  • bone pain
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • nervousness
  • pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • pounding in the ears
  • slow or fast heartbeat
  • sweating

Some side effects of velaglucerase alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • back pain
  • joint pain
  • lack or loss of strength

Less common

  • Feeling of warmth
  • hives or welts
  • itching
  • redness of the skin
  • redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to velaglucerase alfa: intravenous powder for injection


The most common side effects were hypersensitivity/infusion-related reactions. The most serious side effects reported were hypersensitivity reactions.


The term "hypersensitivity reaction" included any event related to and occurring within up to 24 hours of drug infusion, including at least 1 case of anaphylaxis.

The most common symptoms of hypersensitivity reactions were headache, dizziness, hypotension, hypertension, nausea, fatigue/asthenia, and pyrexia; reactions were generally mild. In therapy-naive patients, onset was usually during the first 6 months of therapy and occurred less often over time.

Very common (10% or more): Hypersensitivity reaction (up to 52%)

Frequency not reported: Anaphylaxis, anaphylactoid reaction

Nervous system

Very common (10% or more): Headache (up to 35%), dizziness (up to 22%)

Frequency not reported: Paresthesia


Very common (10% or more): Pyrexia/increased body temperature (up to 22%), asthenia/fatigue (13%), infusion-related reaction

Common (1% to 10%): Flushing

Frequency not reported: Peripheral edema, influenza-like illness


Very common (10% or more): Abdominal pain (up to 19%)

Common (1% to 10%): Nausea, upper abdominal pain

Frequency not reported: Diarrhea, vomiting


Very common (10% or more): Back pain (up to 18%), knee joint pain (up to 15%), arthralgia, bone pain

Frequency not reported: Muscle spasm, myalgia, neck pain


Very common (10% or more): Prolonged activated partial thromboplastin time (up to 11%)


Common (1% to 10%): Tachycardia, hypertension, hypotension


Common (1% to 10%): Rash, urticaria

Frequency not reported: Allergic dermatitis, tinea versicolor, pruritus


Common (1% to 10%): IgG antibodies to velaglucerase alfa (the active ingredient contained in VPRIV) positive for neutralizing antibody


Frequency not reported: Influenza, nasopharyngitis, rhinitis, bronchitis, cough, epistaxis


Frequency not reported: Cystitis, urinary tract infection

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Vpriv