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Generic Name: sofosbuvir, velpatasvir, and voxilaprevir (soe FOS bue vir, vel PAT as vir, and VOX i LA pre vir)
Brand Names: Vosevi
Vosevi (sofosbuvir,velpatasvir and voxilaprevir) is used to treat chronic hepatitis C. Includes Vosevi side effects, interactions and indications.
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Drug Information:
Vosevi contains a combination of sofosbuvir, velpatasvir, and voxilaprevir. Sofosbuvir, velpatasvir, and voxilaprevir are antiviral medications that prevent hepatitis C virus (HCV) from multiplying in your body. Vosevi is a combination medicine used to treat chronic hepatitis C in adults. It is usually given after other treatments have failed. Vosevi treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people. Learn more

Vosevi Side Effects

Vosevi Side Effects

Note: This document contains side effect information about sofosbuvir / velpatasvir / voxilaprevir. Some of the dosage forms listed on this page may not apply to the brand name Vosevi.

For the Consumer

Applies to sofosbuvir/velpatasvir/voxilaprevir: oral tablet


Oral route (Tablet)

Test all patients for evidence of current or prior hepatitis B virus (HBV) infection before initiating treatment with sofosbuvir / velpatasvir / voxilaprevir. HBV reactivation has been reported in HCV/HBV coinfected patients who were undergoing or had completed treatment with HCV direct-acting antivirals and were not receiving HBV antiviral therapy. Some cases have resulted in fulminant hepatitis, hepatic failure, and death. Monitor HCV/HBV coinfected patients for hepatitis flare or HBV reactivation during HCV treatment and post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated.

Along with its needed effects, sofosbuvir / velpatasvir / voxilaprevir may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sofosbuvir / velpatasvir / voxilaprevir:

Incidence not known

  • Chest pain or discomfort
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • skin rash, sometimes with blisters or hive-like swelling
  • slow or irregular heartbeat
  • unusual tiredness or weakness

Some side effects of sofosbuvir / velpatasvir / voxilaprevir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • headache
  • lack or loss of strength
  • nausea

Less common

  • Discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • tiredness
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to sofosbuvir / velpatasvir / voxilaprevir: oral tablet


The most common side effects reported with this drug were headache, fatigue, diarrhea, and nausea. This drug was permanently discontinued due to side effects in up to 0.2% of patients.

Nervous system

Very common (10% or more): Headache (up to 27%)


Very common (10% or more): Fatigue (up to 24%)

Common (1% to 10%): Asthenia


Very common (10% or more): Diarrhea (up to 20%), nausea (up to 14%)

Common (1% to 10%): Elevated lipase, abdominal pain, vomiting

Isolated, asymptomatic lipase elevations (greater than 3 times the upper limit of normal [3 x ULN]) were reported in 2% of patients.


Very common (10% or more): Increased total bilirubin (up to 13%)

Due to inhibition of OATP1B1 and OATP1B3 by voxilaprevir, increased total bilirubin (up to 1.5 x ULN) occurred with this drug. No jaundice was observed and total bilirubin levels decreased after completion of therapy.


Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Depressed mood


Severe bradycardia and heart block have been reported when sofosbuvir plus another direct-acting antiviral was used with concomitant amiodarone and/or other agents that lower heart rate.

Serious symptomatic bradycardia has been reported in patients taking amiodarone who started therapy with a regimen containing sofosbuvir.

Sofosbuvir-containing regimens:

-Frequency not reported: Severe bradycardia, heart block

-Postmarketing reports: Serious symptomatic bradycardia (including fatal cardiac arrest, cases requiring pacemaker intervention)


Common (1% to 10%): Rash

Sofosbuvir-containing regimens:

-Postmarketing reports: Skin rashes (sometimes with blisters or angioedema-like swelling), angioedema


Common (1% to 10%): Back pain, myalgia

Uncommon (0.1% to 1%): Elevated creatine kinase, muscle spasm

Isolated, asymptomatic creatine kinase elevations (at least 10 x ULN) were reported in up to 1% of patients.


Common (1% to 10%): Decreased appetite

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Vosevi