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Generic Name: lacosamide (oral/injection) (la KOE sa mide)
Brand Names: Vimpat
Vimpat is used to treat partial onset seizures in adults and children with epilepsy who are at least 4 years old. Learn about side effects, interactions and indications.
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Drug Information:
Vimpat (lacosamide) is an anti-epileptic drug, also called an anticonvulsant. Vimpat is used together with other medications to treat partial-onset seizures in adults and children with epilepsy. Vimpat tablets and oral solution are for use in adults and children who are at least 4 years old. Vimpat injection is for use only in adults. Do not stop using Vimpat suddenly or you may have increased seizures. Some people have thoughts about suicide while using Vimpat. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Learn more

Vimpat Side Effects

Vimpat Side Effects

Note: This document contains side effect information about lacosamide. Some of the dosage forms listed on this page may not apply to the brand name Vimpat.

In Summary

Common side effects of Vimpat include: blurred vision, diplopia, dizziness, fatigue, headache, nausea, nystagmus disorder, tremor, vomiting, and ataxia. Other side effects include: abnormal gait, asthenia, memory impairment, and vertigo. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lacosamide: oral solution, oral tablet

Other dosage forms:

  • intravenous solution

Along with its needed effects, lacosamide (the active ingredient contained in Vimpat) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lacosamide:

More common

  • Dizziness
  • false or unusual sense of well-being
  • shakiness and unsteady walk
  • sleepiness or unusual drowsiness
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

Less common

  • Being forgetful
  • discouragement
  • feeling sad or empty
  • irritability
  • itching skin
  • lack of appetite
  • loss of balance control
  • loss of interest or pleasure
  • mood or mental changes
  • tearing of the skin
  • tiredness
  • trouble concentrating
  • trouble with sleeping
  • trouble with walking

Incidence not known

  • Abnormal or decreased touch sensation
  • black, tarry stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in patterns and rhythms of speech
  • chills
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling drunk
  • fever
  • hearing loss
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • slurred speech
  • sore throat
  • trouble performing routine tasks
  • trouble with balance
  • trouble with speaking
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of lacosamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Blurred vision
  • double vision
  • headache
  • nausea
  • vomiting

Less common

  • Diarrhea
  • feeling of constant movement of self or surroundings
  • lack or loss of strength
  • sensation of spinning
  • uncontrolled eye movements

Incidence not known

  • Belching
  • difficulty having a bowel movement
  • dry mouth
  • heartburn
  • indigestion
  • muscle spasms
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to lacosamide: intravenous solution, oral solution, oral tablet


The most commonly reported adverse reactions have included diplopia, headache, dizziness, and nausea.

Nervous system

Dizziness was reported in 25% of patients randomized to the recommended doses (200 to 400 mg/day) of this drug compared with 8% of placebo patients in studies in adult patients with partial-onset seizures taking 1 to 3 concomitant AEDs. It was the event most frequently leading to discontinuation (3%). Ataxia was reported by 6% of patients randomized to the recommended doses (200 to 400 mg/day) compared to 2% in placebo patients. Dizziness and ataxia were also observed in pediatric clinical trials.

Very common (10% or more): Dizziness (up to 60%), headache (up to 13%), ataxia (up to 15%)

Common (1% to 10%): Somnolence, tremor, balance disorder, nystagmus, memory impairment, coordination abnormal, cognitive disorder, somnolence, tremor, dysarthria, disturbance in attention, paresthesia

Frequency not reported: Oral hypoesthesia, pyrexia

Postmarketing reports: Hypoesthesia, cerebellar syndrome, new or worsening seizures


Very common (10% or more): Nausea (up to 24%), vomiting (up to 16%)

Common (1% to 10%): Diarrhea, constipation, flatulence, dyspepsia, dry mouth


Very common (10% or more): Diplopia (up to 16%), blurred vision (up to 16%)


Uncommon (0.1% to 1%): Hypersensitivity

Frequency not reported: Multiorgan hypersensitivity reactions (also known as Drug Reaction with Eosinophilia and Systemic Symptoms, or DRESS)


Very common (10% or more): Fatigue (up to 15%)

Common (1% to 10%): Asthenia, vertigo, gait disturbance

Frequency not reported: Tinnitus, fall


Common (1% to 10%): Injection site pain or discomfort

Uncommon (0.1% to 1%): Irritation, erythema


Common (1% to 10%): Depression, confusional state, insomnia

Uncommon (0.1% to 1%): Aggression, agitation, euphoric mood, suicide attempt, suicidal ideation, hallucination

Frequency not reported: Irritability, feeling drunk

Postmarketing reports: Psychotic disorder


Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Angioedema, urticaria

Frequency not reported: Neutropenia, anemia

Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis


During clinical trials in adult patients with partial-onset seizures, asymptomatic first-degree atrioventricular (AV) block was observed in 0.4% (4/944) of patients randomized to this drug and 0% (0/364) of placebo patients. One case of profound bradycardia was observed in a patient during a 15-minute 150 mg IV infusion.

In short-term trials in adult patients with diabetic neuropathy, atrial fibrillation occurred in 0.5% of patients (placebo=0%). Syncope occurred in 1.2% of patients (placebo=0%).

A clinical pharmacology study in healthy subjects (n=247) did not shown any QTc interval prolongation or dose-related or clinically important effects on QRS duration. This drug did produce a dose-related increase in mean PR interval; the maximum mean PR interval increase corresponded with Tmax. The placebo-subtracted maximum increase in PR interval was 7.3 ms for the 400 mg/day group and 11.9 ms for the 800 mg/day group. In clinical trials, the placebo-subtracted mean maximum increase in PR interval for a 400 mg/day dose was 3.1 ms in patients with partial-onset seizures and 9.4 ms for patients with diabetic neuropathy.

Very common (10% or more): Chest pain (up to 12%)

Common (1% to 10%): Syncope

Uncommon (0.1% to 1%): Atrioventricular block, bradycardia, atrial fibrillation, atrial flutter

Frequency not reported: Palpitations

Postmarketing reports: Cardiac arrhythmias including bradycardia, AV block, and ventricular tachyarrhythmia, which have rarely resulted in asystole, cardiac arrest, and death


Common (1% to 10%): Muscle spasms

Frequency not reported: Connective tissue disorders


Frequency not reported: Neutropenia, anemia

Postmarketing reports: Agranulocytosis


Uncommon (0.1% to 1%): Liver function test abnormal

Frequency not reported: Hepatitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Vimpat