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Generic Name: abemaciclib (a BEM a SYE klib)
Brand Names: Verzenio
Verzenio (abemaciclib) is used to treat breast cancer. Includes Verzenio side effects, interactions and indications.
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Drug Information:
Verzenio (abemaciclib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Verzenio is used to treat advanced hormone-related breast cancer. Verzenio is used for this condition only if your tumor tests negative for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells. Verzenio is used when the cancer has progressed or has spread to other parts of the body after treatment with anti-estrogen medication or other chemotherapy. Learn more

Verzenio Side Effects

Verzenio Side Effects

Note: This document contains side effect information about abemaciclib. Some of the dosage forms listed on this page may not apply to the brand name Verzenio.

For the Consumer

Applies to abemaciclib: oral tablet

Along with its needed effects, abemaciclib (the active ingredient contained in Verzenio) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking abemaciclib:

More common

  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • chest pain
  • chills
  • confusion
  • cough
  • decreased urination
  • diarrhea
  • difficulty breathing
  • dizziness
  • dry mouth
  • fainting
  • fever
  • hoarseness
  • increased heart rate
  • irregular heartbeat
  • lightheadedness
  • lower back or side pain
  • pain in the chest, groin, or legs, especially the calves
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid breathing
  • rapid weight gain
  • severe, sudden headache
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sunken eyes
  • swollen glands
  • thirst
  • tingling of the hands or feet
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vision changes
  • wrinkled skin


  • Blurred vision
  • clay-colored stools
  • dark urine
  • decreased appetite
  • fast heartbeat
  • general feeling of discomfort or illness
  • itching
  • loss of appetite
  • nausea
  • numbness or tingling in the face, arms, or legs
  • rapid, shallow breathing
  • severe headache
  • skin rash
  • stomach pain or tenderness
  • swelling of the feet or lower legs
  • thickening of bronchial secretions
  • trouble speaking or walking
  • vomiting
  • yellow eyes or skin

Some side effects of abemaciclib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change in taste
  • dry mouth
  • loss of taste
  • loss or thinning of hair
  • swelling or inflammation of the mouth

For Healthcare Professionals

Applies to abemaciclib: oral tablet


The most common adverse reactions reported (20% or greater incidence) were increased creatinine (98%), decreased white blood cell count (91%), diarrhea (90%), decreased neutrophil count (88%), anemia (84%), fatigue/asthenia (65%), nausea (64%), decreased lymphocyte count (63%), decreased platelet count (53%), neutropenia (46%), decreased appetite (45%), infections (43%), increased ALT (41%), abdominal pain (39%), increased AST (37%), vomiting (35%), leukopenia (28%), and thrombocytopenia (20%).


Very common (10% or more): Increased creatinine (98%)


Very common (10% or more): Decreased white blood cell count (91%), decreased neutrophil count (88%), anemia (84%), decreased lymphocyte count (63%), decreased platelet count (53%), neutropenia (46%), leukopenia (28%), thrombocytopenia (20%)

Common (1% to 10%): Febrile neutropenia

Frequency not reported: Neutropenic sepsis


Very common (10% or more): Diarrhea (90%), nausea (64%), abdominal pain (39%), vomiting (35%), constipation (17%), stomatitis (15%), dry mouth (14%)


Very common (10% or more): Fatigue/asthenia (65%), infections (43%), peripheral edema (12%), pyrexia (11%)

Reported infections included upper respiratory tract infection, urinary tract infection, lung infection, pharyngitis, conjunctivitis, sinusitis, vaginal infection, and sepsis.


Very common (10% or more): Decreased appetite (45%), decreased weight (14%), dehydration (10%)


Very common (10% or more): Increased ALT (41%), increased AST (37%)


Very common (10% or more): Cough (19%)

Nervous system

Very common (10% or more): Headache (20%), dysgeusia (18%), dizziness (12%)


Very common (10% or more): Alopecia (16%), pruritus (13%), rash (11%)


Very common (10% or more): Arthralgia (15%)


Common (1% to 10%): Venous thromboembolic events

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Verzenio