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Generic Name: iloprost inhalation (ill O prost)
Brand Names: Ventavis
Ventavis is used as an inhalant to treat pulmonary arterial hypertension. Learn about side effects, interactions and indications.
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Drug Information:
Ventavis (iloprost) is an synthetic prostacyclin. It works by opening blood vessels in the lungs. Ventavis inhalation is used to treat pulmonary arterial hypertension (PAH). It decreases symptoms of this condition and improves your ability to exercise. Ventavis may also be used for purposes not listed in this medication guide. Before using Ventavis, tell your doctor if you have liver or kidney disease, heart disease, low blood pressure, asthma or COPD, or a chest cold with cough. Ventavis inhalation is usually given 6 to 9 times per day. Your doses should not be spaced less than 2 hours apart, even if you feel like the effects of the medicine have worn off in less than 2 hours. Learn more

Ventavis Side Effects

Ventavis Side Effects

Note: This document contains side effect information about iloprost. Some of the dosage forms listed on this page may not apply to the brand name Ventavis.

In Summary

Common side effects of Ventavis include: trismus, increased cough, vasodilation, and flushing. Other side effects include: glossalgia, and insomnia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to iloprost: inhalation solution

Along with its needed effects, iloprost (the active ingredient contained in Ventavis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking iloprost:

Incidence not known

  • Black, tarry stools
  • chest pain
  • cough
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hives or rash
  • irregular breathing
  • itching
  • noisy breathing
  • pinpoint red spots on the skin
  • swelling of the eyelids, face, lips, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual bleeding or bruising

Some side effects of iloprost may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • chills
  • cough increased
  • coughing or spitting up blood
  • difficulty opening the mouth
  • feeling of warmth
  • headache
  • lockjaw
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • sweating
  • trouble sleeping

Less common

  • Change in taste
  • mouth irritation
  • tongue irritation or pain

Incidence not known

  • Nosebleeds
  • stuffy nose

For Healthcare Professionals

Applies to iloprost: inhalation solution


The most frequently reported side effects were vasodilation (flushing), cough increased, headache, trismus, insomnia, nausea, hypotension, vomiting, alkaline phosphatase increased, flu syndrome, back pain, tongue pain, palpitations, syncope, GGT increased, muscle cramps, hemoptysis, and pneumonia.


Very common (10% or more): Vasodilation/flushing (up to 27%), hypotension (up to 11%)

Common (1% to 10%): Tachycardia, palpitation

Frequency not reported: Congestive heart failure, supraventricular tachycardia


Very common (10% or more): Nausea (up to 13%)

Common (1% to 10%): Diarrhea, vomiting, mouth/tongue irritation, mouth/tongue pain

Frequency not reported: Dysgeusia

Nervous system

Very common (10% or more): Headache (up to 30%)

Common (1% to 10%): Dizziness, syncope


Very common (10% or more): Cough increased (up to 39%), epistaxis, hemoptysis

Common (1% to 10%): Dyspnea, pharyngolaryngeal pain, throat irritation, pneumonia

Frequency not reported: Bronchospasm, wheezing

Postmarketing reports: Nasal congestion


Very common (10% or more): Pain in jaw/trismus (up to 12%)

Common (1% to 10%): Back pain, muscle cramps


Frequency not reported: Kidney failure


Very common (10% or more): Flu-like syndrome (14%), peripheral edema (up to 12.2%), chest discomfort/chest pain

Common (1% to 10%): Alkaline phosphatase increased, GGT increased


Common (1% to 10%): Rash


Very common (10% or more): Bleeding events

Frequency not reported: Thrombocytopenia


Frequency not reported: Hypersensitivity


Common (1% to 10%): Insomnia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Ventavis