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Generic Name: hydrochlorothiazide and enalapril (HYE droe KLOR oh THYE a zide and en AL e pril)
Brand Name: Vaseretic 10-25
Physician reviewed Vaseretic 10-25 patient information - includes Vaseretic 10-25 description, dosage and directions.
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Drug Information:
Hydrochlorothiazide is a thiazide diuretic (water pill) and enalapril is an ACE inhibitor (ACE stands for angiotensin converting enzyme). Vaseretic 10-25 is a combination medicine used to treat hypertension (high blood pressure). Vaseretic 10-25 may also be used for purposes not listed in this medication guide. Do not use if you are pregnant. If you become pregnant, stop taking Vaseretic 10-25 and tell your doctor right away. You should not use this medicine if you are unable to urinate, if you have ever had angioedema, or if you are allergic to sulfa drugs or any ACE inhibitor. Do not take Vaseretic 10-25 within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). Learn more

Vaseretic Side Effects

Vaseretic Side Effects

Note: This document contains side effect information about enalapril / hydrochlorothiazide. Some of the dosage forms listed on this page may not apply to the brand name Vaseretic.

In Summary

Common side effects of Vaseretic include: increased blood urea nitrogen and increased serum creatinine. Other side effects include: dizziness and headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to enalapril / hydrochlorothiazide: oral tablet


Oral route (Tablet)

Discontinue enalapril maleate/hydrochlorothiazide as soon as possible when pregnancy is detected, since fetal toxicity, including injury and death to the developing fetus, can be caused by drugs that act directly on the renin-angiotensin system.

Along with its needed effects, enalapril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enalapril / hydrochlorothiazide:

Less common

  • Blurred vision
  • chest pain or discomfort
  • chills
  • cold sweats
  • coma
  • confusion
  • decreased urine output
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • increased thirst
  • irritability
  • loss of appetite
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • swelling of the face, ankles, or hands
  • thirst
  • unusual tiredness or weakness
  • weak pulse
  • wrinkled skin

Some side effects of enalapril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Cough
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance

For Healthcare Professionals

Applies to enalapril / hydrochlorothiazide: oral tablet


The most common adverse reactions were dizziness, headache, fatigue, and cough.

Nervous system

Common (1% to 10%): Dizziness, headache, syncope

Frequency not reported: Paresthesia, somnolence, vertigo, tinnitus


Postmarketing reports: Cerebrovascular accident, ataxia, peripheral neuropathy, paresthesia, dysesthesia, taste alteration, anosmia


Common (1% to 10%): Fatigue, asthenia, orthostatic effects

Frequency not reported: Chest pain


Postmarketing reports: Gynecomastia


Frequency not reported: Weakness, fever


Common (1% to 10%): Cough

Frequency not reported: Dyspnea


Postmarketing reports: Pulmonary embolism and infarction, pulmonary edema


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema


Common (1% to 10%): Muscle cramps

Frequency not reported: Back pain, arthralgia


Postmarketing reports: Flank pain


Frequency not reported: Muscle spasm


Common (1% to 10%): Nausea, diarrhea

Frequency not reported: Abdominal pain, vomiting, dyspepsia, constipation, flatulence, dry mouth


Postmarketing reports: Ileus, pancreatitis, melena, glossitis, stomatitis, dry mouth


Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation


Common (1% to 10%): Impotence

Frequency not reported: Urinary tract infection


Postmarketing reports: Oliguria


Common (1% to 10%): Orthostatic hypotension

Uncommon (0.1% to 1%): Hypotension

Frequency not reported: Palpitation, tachycardia


Postmarketing reports: Cardiac arrest, myocardial infarction, rhythm disturbances, atrial tachycardia and bradycardia, atrial fibrillation, hypotension, angina pectoris, Raynaud's phenomenon, flushing


Frequency not reported: Vasculitis


Uncommon (0.1% to 1%): BUN increased, serum creatinine increased


Postmarketing reports: Renal failure, renal dysfunction, pulmonary infiltrates, eosinophilic pneumonitis, bronchospasm, pneumonia, bronchitis, rhinorrhea, sore throat and hoarseness, asthma, upper respiratory infection


Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis


Frequency not reported: Pruritus, rash, diaphoresis, angioedema


Postmarketing reports: Exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome, herpes zoster, erythema multiforme, urticaria, pemphigus, alopecia, photosensitivity


Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, alopecia


Frequency not reported: Insomnia, nervousness, libido decreased


Postmarketing reports: Depression, confusion, dream abnormality


Frequency not reported: Restlessness


Frequency not reported: Hemoglobin decreased, hematocrit decreased


Postmarketing reports: Neutropenia, thrombocytopenia, bone marrow depression, hemolytic anemia


Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia


Frequency not reported: Liver enzymes increased, serum bilirubin increased


Postmarketing reports: Hepatic failure, hepatitis


Frequency not reported: Intrahepatic cholestatic jaundice


Frequency not reported: Gout

Postmarketing reports: Anorexia


Frequency not reported: Anorexia



Postmarketing reports: Blurred vision, conjunctivitis, dry eyes, tearing


Frequency not reported: Transient blurred vision, xanthopsia



Postmarketing reports: Anaphylactoid reactions


Frequency not reported: Anaphylactic reactions

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Vaseretic