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Generic Name: rolapitant (roe LA pi tant)
Brand Names: Varubi
Varubi (rolapitant) is used to treat chemotherapy-induced nausea and vomiting. Includes Varubi side effects, interactions and indications.
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Drug Information:
Varubi (rolapitant) blocks the actions of chemicals in the body that trigger nausea and vomiting. Varubi is used together with other medicines to prevent nausea and vomiting caused by cancer chemotherapy. Varubi may also be used for purposes not listed in this medication guide. Varubi can cause a rapid and severe allergic reaction. Tell your doctor if you have a history of allergies to any food or medicines. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Learn more

Varubi Side Effects

Varubi Side Effects

Note: This document contains side effect information about rolapitant. Some of the dosage forms listed on this page may not apply to the brand name Varubi.

For the Consumer

Applies to rolapitant: oral tablet

Other dosage forms:

  • intravenous emulsion

Along with its needed effects, rolapitant (the active ingredient contained in Varubi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rolapitant:

More common

  • Black, tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • shortness of breath
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • troubled breathing with exertion

Some side effects of rolapitant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decreased appetite
  • dizziness

Less common

  • Acid or sour stomach
  • belching
  • heartburn
  • hiccups
  • indigestion
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to rolapitant: intravenous emulsion, oral tablet


Common (1% to 10%): Neutropenia, anemia


Common (1% to 10%): Decreased appetite

Nervous system

Common (1% to 10%): Dizziness


Common (1% to 10%): Hiccups


Common (1% to 10%): Abdominal pain, dyspepsia, stomatitis


Common (1% to 10%): Urinary tract infection

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Varubi