Note: This document contains side effect information about ampicillin / sulbactam. Some of the dosage forms listed on this page may not apply to the brand name Unasyn.
Applies to ampicillin / sulbactam: injection powder for solution
Along with its needed effects, ampicillin/sulbactam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking ampicillin / sulbactam:
Incidence not known
Some side effects of ampicillin / sulbactam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to ampicillin / sulbactam: injectable powder for injection
This drug was generally well-tolerated.
Very common (10% or more): Pain at IM injection site (16%)
Common (1% to 10%): Pain at IV injection site, thrombophlebitis, phlebitis
Postmarketing reports: Injections site reaction
Common (1% to 10%): Diarrhea
Uncommon (0.1% to 1%): Nausea, vomiting, flatulence, abdominal distension, glossitis
Frequency not reported: Pancreatitis, enterocolitis, pseudomembranous colitis
Postmarketing reports: Gastritis, stomatitis, black "hairy" tongue, Clostridium difficile associated diarrhea
Frequency not reported: Hypersensitivity reactions to ampicillin (including urticarial rash, edema, hypotension, fever, eosinophilia, dyspnea, delayed hypersensitivity maculopapular rash, anaphylaxis, interstitial nephritis, Henoch-Schonlein purpura, focal glomerulonephritis, Stevens-Johnson syndrome)
Postmarketing reports: Serious and fatal hypersensitivity (anaphylactic) reactions
Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Itching, facial swelling, erythema
Frequency not reported: Ampicillin-associated bullous pemphigoid, linear IgA dermatosis, pseudoporphyria
Postmarketing reports: Erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, urticaria, exfoliative dermatitis
Hemolytic anemia, thrombocytopenic purpura, and agranulocytosis were generally reversible when therapy was discontinued; may be hypersensitivity events.
Frequency not reported: Decreased hemoglobin, decreased hematocrit, decreased red blood cells, decreased white blood cells, decreased neutrophils, decreased lymphocytes, decreased platelets, increased lymphocytes, increased monocytes, increased basophils, increased eosinophils, increased platelets, thrombocytopenia, leukopenia, red cell aplasia, anemia, atypical lymphocytosis
Postmarketing reports: Hemolytic anemia, thrombocytopenic purpura, agranulocytosis, positive direct Coombs test
Uncommon (0.1% to 1%): Headache
Frequency not reported: Seizures, neurotoxic potential, worsening myasthenia gravis symptoms
Postmarketing reports: Convulsion
Seizures have been reported in very ill patients with high serum levels of ampicillin. High cerebral spinal fluid (CSF) levels of some penicillins are potentially neurotoxic; the CSF levels of ampicillin rise significantly in meningitis.
Frequency not reported: Increased AST, increased ALT, hepatitis, prolonged cholestasis
Postmarketing reports: Cholestatic hepatitis, cholestasis, hyperbilirubinemia, jaundice, abnormal hepatic function
Frequency not reported: Increased alkaline phosphatase, increased lactate dehydrogenase, decreased serum albumin, decreased total protein
Uncommon (0.1% to 1%): Urine retention, dysuria
Frequency not reported: Urinary red blood cells, urinary hyaline casts
Frequency not reported: Increased BUN, increased creatinine
Postmarketing reports: Tubulointerstitial nephritis
Uncommon (0.1% to 1%): Candidiasis, fatigue, malaise, chest pain, edema, chills, substernal pain, mucosal bleeding
Uncommon (0.1% to 1%): Throat tightness, epistaxis
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Unasyn