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Generic Name: dorzolamide ophthalmic (dor ZOL a mide)
Brand Name: Trusopt
Physician reviewed Trusopt patient information - includes Trusopt description, dosage and directions.
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Drug Information:
Dorzolamide reduces the amount of fluid in the eye, which decreases pressure inside the eye. Trusopt (for the eyes) is used to treat open-angle glaucoma and other causes of high pressure inside the eye. Trusopt may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. You should not use Trusopt if you are allergic to it. Learn more

Trusopt Side Effects

Trusopt Side Effects

Note: This document contains side effect information about dorzolamide ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Trusopt.

In Summary

Common side effects of Trusopt include: burning sensation of eyes, eye discomfort, eye pruritus, local ocular hypersensitivity reaction, stinging of eyes, superficial punctate keratitis, swelling of eye, bitter taste, eye irritation, and eye redness. Other side effects include: blurred vision, lacrimation, photophobia, and xerophthalmia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dorzolamide ophthalmic: ophthalmic solution

Along with its needed effects, dorzolamide ophthalmic (the active ingredient contained in Trusopt) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dorzolamide ophthalmic:

More common

  • Burning, stinging, or discomfort when medicine is applied
  • itching, redness, swelling, or other sign of the eye or eyelid irritation

Less common

  • Burning, dry, or itching eyes
  • discharge from the eye
  • excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid


  • Blood in the urine
  • blurred vision
  • nausea or vomiting
  • pain in the side, back, or abdomen
  • skin rash
  • tearing

Incidence not known

  • Blistering, burning, crusting, dryness, or flaking of the skin
  • change in vision
  • chills
  • cough
  • diarrhea
  • difficult or labored breathing
  • flashes of light
  • floaters in vision
  • hives or welts
  • itching skin
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • redness of the skin
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking dorzolamide ophthalmic:

Symptoms of overdose

  • Confusion
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • seizures
  • trembling
  • weakness and heaviness of the legs

Some side effects of dorzolamide ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bitter taste
  • feeling of something in the eye

Less common

  • Changes in color vision
  • difficulty seeing at night
  • dryness of the eyes
  • eyelid reactions
  • headache
  • increased sensitivity of the eyes to sunlight

Incidence not known

  • Bloody nose
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in distance vision
  • difficulty in focusing the eyes
  • dizziness
  • dry mouth
  • eyelid crusting
  • lack or loss of strength
  • scaling of the skin
  • severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to dorzolamide ophthalmic: ophthalmic solution


The most commonly reported side effects were ocular burning, stinging, or discomfort, and bitter taste.


Very common (10% or more): Superficial punctate keratitis (up to 15%), burning/stinging

Common (1% to 10%): Tearing, conjunctivitis, eyelid inflammation, eye itching, eyelid irritation, blurred vision

Uncommon (0.1% to 1%): Iridocyclitis

Rare (less than 0.1%): Irritation, pain, eyelid crusting, transient myopia, corneal edema, ocular hypotony, choroidal detachment following filtration surgery


Very common (10% or more): Ocular allergic reaction (10%)

Rare (less than 0.1%): Signs and symptoms of local reactions (palpebral reactions) and systemic allergic reactions including angioedema, urticaria, pruritus, rash, shortness of breath, bronchospasm


Rare (less than 0.1%): Urolithiasis


Rare (less than 0.1%): Epistaxis

Frequency not reported: Dyspnea


Uncommon (0.1% to 1%): Contact dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis

Rare (less than 0.1%): Skin rash

Nervous system

Very common (10% or more): Biter taste (up to 25%)

Frequency not reported: Headache


Common (1% to 10%): Nausea

Rare (less than 0.1%): Throat irritation, dry mouth


Common (1% to 10%): Asthenia/fatigue

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Trusopt