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Generic Name: plecanatide (ple KAN a tide)
Brand Names: Trulance
Trulance (plecanatide) is used to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Includes Trulance side effects, interactions and indications.
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Drug Information:
Trulance (plecanatide) is used to treat chronic idiopathic constipation or irritable bowel syndrome with constipation. Trulance works by activating certain substances within your intestines that help increase fluid secretion and muscle movement. Trulance also causes changes in the consistency of your stools. You should not use Trulance if you are allergic to plecanatide, or if you have a blockage in your intestines. Adults who cannot swallow Trulance tablets whole may crush the tablet and mix with applesauce or dissolve the tablet in water before swallowing. Trulance tablets may also be taken with water by adults through a nasogastric or gastric feeding tube. Learn more

Trulance Side Effects

Trulance Side Effects

Note: This document contains side effect information about plecanatide. Some of the dosage forms listed on this page may not apply to the brand name Trulance.

In Summary

More frequent side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to plecanatide: oral tablet


Oral route (Tablet)

Plecanatide is contraindicated in patients less than 6 years of age; in nonclinical studies in young juvenile mice administration of a single oral dose of plecanatide caused deaths due to dehydration. Avoid use of plecanatide in patients 6 years to less than 18 years of age. The safety and effectiveness of plecanatide have not been established in patients less than 18 years of age.

Along with its needed effects, plecanatide (the active ingredient contained in Trulance) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking plecanatide:

Less common

  • Severe diarrhea

Some side effects of plecanatide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Bladder pain
  • bloody or cloudy urine
  • body aches or pain
  • chills
  • cough
  • difficult, burning, or painful urination
  • difficulty with breathing
  • dizziness
  • ear congestion
  • excess air or gas in the stomach or bowels
  • fever
  • full or bloated feeling
  • headache
  • loss of voice
  • lower back or side pain
  • muscle aches
  • nasal congestion
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • passing gas
  • pressure in the stomach
  • sneezing
  • sore throat
  • stuffy or runny nose
  • swelling of the abdominal or stomach area
  • tightness of the chest
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to plecanatide: oral tablet


Common (1% to 10%): Diarrhea

Frequency not reported: Abdominal distention, flatulence, abdominal tenderness


In clinical trials, there were 2 patients with ALT greater than 5 to 15 times the upper limit of normal (ULN) and 3 patients with AST greater than 5 x ULN.

Frequency not reported: Increased liver biochemical tests


Frequency not reported: Sinusitis, upper respiratory tract infection

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Trulance