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Generic Name: amlodipine, hydrochlorothiazide, and olmesartan (am LOE di peen, HYE droe KLOR oh THYE a zide, and OL me SAR tan)
Brand Names: Tribenzor
Tribenzor (olmesartan medoxomil, amlodipine, hydrochlorothiazide) is used to treat high blood pressure (hypertension). Includes Tribenzor side effects, interactions and indications.
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Drug Information:
Tribenzor contains a combination of amlodipine, hydrochlorothiazide, and olmesartan. Amlodipine is a calcium channel blocker that relaxes (widens) blood vessels and improves blood flow. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Olmesartan is an angiotensin II receptor antagonist that keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Tribenzor is used to treat high blood pressure (hypertension). Learn more

Tribenzor Side Effects

Tribenzor Side Effects

Note: This document contains side effect information about amlodipine / hydrochlorothiazide / olmesartan. Some of the dosage forms listed on this page may not apply to the brand name Tribenzor.

For the Consumer

Applies to amlodipine / hydrochlorothiazide / olmesartan: oral tablet


Oral route (Tablet)

Drugs that act directly on the renin-angiotensin system can cause fetal toxicity, including injury and even death to the developing fetus. When pregnancy is confirmed, discontinue immediately.

Along with its needed effects, amlodipine/hydrochlorothiazide/olmesartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine/hydrochlorothiazide/olmesartan:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss

Less common

  • Bladder pain
  • bloody or cloudy urine
  • body aches or pain
  • cough
  • difficult, burning, or painful urination
  • difficulty with breathing
  • fainting
  • frequent urge to urinate
  • headache
  • loss of voice
  • lower back or side pain
  • swelling of the joints
  • unusual tiredness or weakness

Some side effects of amlodipine / hydrochlorothiazide / olmesartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Diarrhea
  • muscle aches or spasms
  • nausea

For Healthcare Professionals

Applies to amlodipine / hydrochlorothiazide / olmesartan: oral tablet


The most common adverse reactions were dizziness, peripheral edema, and headache.

Nervous system

Common (1% to 10%): Dizziness, headache, syncope

Uncommon (0.1% to 1%): Hypoesthesia, lethargy, paresthesia, postural dizziness, vertigo


Common (1% to 10%): Dizziness, headache, somnolence

Uncommon (0.1% to 1%): Hypoesthesia, paresthesia, syncope, tremor, tinnitus, postural dizziness, peripheral neuropathy

Rare (less than 0.1%): Hypertonia, ataxia, migraine, amnesia, parosmia, taste perversion


Frequency not reported: Lightheadedness, vertigo, paresthesia


Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Vertigo

Postmarketing reports: Lethargy


Common (1% to 10%): Nausea, diarrhea

Uncommon (0.1% to 1%): Constipation, dry mouth, dyspepsia, upper abdominal pain, vomiting


Common (1% to 10%): Abdominal pain, nausea, dyspepsia

Uncommon (0.1% to 1%): Altered bowel habits, dry mouth, vomiting, constipation, dysphagia, diarrhea, flatulence, pancreatitis, gingival hyperplasia

Rare (less than 0.1%): Gastritis, loose stools


Frequency not reported: Sialadenitis, cramping, gastric irritation, diarrhea, constipation, pancreatitis


Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, gastroenteritis, nausea

Postmarketing reports: Vomiting, sprue-like enteropathy


Common (1% to 10%): Muscle spasms, joint swelling

Uncommon (0.1% to 1%): Back pain, pain in extremity


Common (1% to 10%): Muscle cramps

Uncommon (0.1% to 1%): Arthralgia, back pain, myalgia, rigors, arthrosis

Rare (less than 0.1%): Muscle weakness, twitching


Frequency not reported: Muscle spasm


Common (1% to 10%): Arthritis, back pain, skeletal pain, creatine phosphokinase increased

Uncommon (0.1% to 1%): Myalgia, arthralgia

Postmarketing reports: Rhabdomyolysis


Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection

Uncommon (0.1% to 1%): Cough, dyspnea


Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Epistaxis

Rare (less than 0.1%): Coughing, rhinitis


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema


Common (1% to 10%): Bronchitis, cough, pharyngitis, rhinitis, sinusitis


Common (1% to 10%): Fatigue, peripheral edema

Uncommon (0.1% to 1%): Asthenia

Rare (less than 0.1%): Face edema


Very common (10% or more): Edema (up to 10.8%)

Common (1% to 10%): Fatigue, asthenia

Uncommon (0.1% to 1%): Malaise, pain, gynecomastia, chest pain


Frequency not reported: Weakness, fever


Common (1% to 10%): Chest pain, fatigue, influenza-like symptoms, pain, peripheral edema

Postmarketing reports: Asthenia, malaise


Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Pollakiuria, erectile dysfunction


Common (1% to 10%): Male sexual dysfunction

Uncommon (0.1% to 1%): Micturition frequency, micturition disorder, nocturia, female sexual dysfunction

Rare (less than 0.1%): Dysuria, polyuria


Frequency not reported: Glycosuria


Common (1% to 10%): Hematuria, urinary tract infection


Uncommon (0.1% to 1%): Palpitations, tachycardia, hypotension, orthostatic hypotension


Common (1% to 10%): Flushing, palpitation

Uncommon (0.1% to 1%): Hypotension, peripheral ischemia, tachycardia, postural hypotension, hot flushes, vasculitis, arrhythmia, bradycardia

Rare (less than 0.1%): Cardiac failure, pulse irregularity, extrasystoles

Frequency not reported: Arrhythmia, myocardial infarction


Frequency not reported: Cardiac arrhythmias, vasculitis, postural hypotension


Uncommon (0.1% to 1%): Angina pectoris, tachycardia

Rare (less than 0.1%): Hypotension


Uncommon (0.1% to 1%): Hyperkalemia, blood potassium decreased


Uncommon (0.1% to 1%): Weight gain, anorexia, thirst, hyperglycemia, weight decrease

Rare (less than 0.1%): Increased appetite


Frequency not reported: Anorexia, loss of appetite, hyperglycemia, hyperuricemia, electrolyte imbalance, hyponatremia, hypokalemia, cholesterol increased, triglycerides increased


Common (1% to 10%): Hypertriglyceridemia, hyperuricemia, hyperglycemia

Rare (less than 0.1%): Hyperkalemia


Common (1% to 10%): Renal function impaired

Uncommon (0.1% to 1%): Blood creatinine increased, blood uric acid increased


Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis


Postmarketing reports: Acute renal failure, blood creatinine increased


Uncommon (0.1% to 1%): Rash

Rare (less than 0.1%): Urticaria


Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Alopecia, pruritus, purpura, rash, sweating increased, angioedema, rash erythematous, rash maculopapular, erythema multiforme

Rare (less than 0.1%): Skin discoloration, urticaria, skin dryness, dermatitis, cold and clammy skin


Frequency not reported: Purpura, photosensitivity, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus, erythematosus, cutaneous vasculitis, erythema multiforme, exfoliative dermatitis


Uncommon (0.1% to 1%): Rash

Postmarketing reports: Angioedema, alopecia, pruritus, urticaria


Uncommon (0.1% to 1%): GGT increased


Postmarketing reports: Hepatic enzymes increased, hepatitis, jaundice


Frequency not reported: Intrahepatic cholestatic jaundice


Common (1% to 10%): Hepatic enzymes increased


Uncommon (0.1% to 1%): Libido decreased


Uncommon (0.1% to 1%): Depression, insomnia, mood changes, nervousness, abnormal dreams, anxiety, depersonalization

Rare (less than 0.1%): Apathy, agitation


Frequency not reported: Restlessness, sleep disturbances, depression


Rare (less than 0.1%): Drug hypersensitivity


Uncommon (0.1% to 1%): Allergic reactions


Frequency not reported: Anaphylactic reactions


Postmarketing reports: Anaphylactic reactions



Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain

Rare (less than 0.1%): Xerophthalmia, abnormal visual accommodation


Frequency not reported: Transient blurred vision, xanthopsia



Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia


Frequency not reported: Aplastic anemia, neutropenia/agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia, bone marrow depression

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tribenzor