Please wait...


Generic Name: fluocinolone, hydroquinone, and tretinoin topical (FLOO oh SIN oh lone, HYE droe KWIN one, TRET in oin)
Brand Name: Tri-Luma
Physician reviewed Tri-Luma patient information - includes Tri-Luma description, dosage and directions.
  • Prescription Settings

Prices and coupons of Tri-luma

Current Location: 20149 (Ashburn)
Change Location?

Enter your zip code

Please wait while the prices are loaded...

Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Drug Information:
Fluocinolone is a steroid that reduces inflammation or swelling. Hydroquinone is a skin bleaching agent. Tretinoin is a form of vitamin A that helps the skin to renew itself more quickly. Tri-Luma (for use on the skin) is a combination medicine used to treat melasma (dark skin patches) on the face. Tri-Luma may also be used for purposes not listed in this medication guide. Avoid exposure to sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Learn more

Tri-luma Side Effects

Tri-Luma Side Effects

Note: This document contains side effect information about fluocinolone / hydroquinone / tretinoin topical. Some of the dosage forms listed on this page may not apply to the brand name Tri-Luma.

In Summary

Common side effects of Tri-Luma include: burning sensation, desquamation, pruritus, erythema of skin, and xeroderma. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to fluocinolone/hydroquinone/tretinoin topical: topical application cream

Along with its needed effects, fluocinolone/hydroquinone/tretinoin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluocinolone/hydroquinone/tretinoin topical:

More common

  • Redness, peeling, drying, itching, or burning of the skin

Less common

  • Darkening of normal skin color
  • irritated skin
  • rash

Incidence not known

  • Blistering, crusting, or flaking of the skin
  • burning and itching of the skin with pinhead-sized red blisters
  • lightening of normal skin color
  • redness and scaling around the mouth
  • severe redness, soreness, or scaling of the skin
  • thinning of the skin with easy bruising

Some side effects of fluocinolone / hydroquinone / tretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Blemishes on the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • pimples
  • raised, dark red, wart-like spots on the skin

For Healthcare Professionals

Applies to fluocinolone / hydroquinone / tretinoin topical: topical cream


The most commonly reported side effects included erythema, desquamation, burning, and dryness.


Very common (10% or more): Erythema (up to 41%), desquamation (up to 38%), dryness (up to 14%), pruritus (up to 11%)

Common (1% to 10%): Acne, telangiectasia, rosacea, papules, acne-like rash, rash, vesicles, pigmentary changes

Postmarketing reports: Itching, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, miliaria, allergic contact dermatitis

Nervous system

Very common (10% or more): Burning (18%)

Common (1% to 10%): Paresthesia


Common (1% to 10%): Irritation


Common (1% to 10%): Dry mouth

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tri-luma