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Generic Name: guselkumab (GUE sel KOO mab)
Brand Names: Tremfya
Tremfya (guselkumab) is a monoclonal antibody that blocks a certain protein in the body that can cause inflammation and other immune responses. Tremfya is used to treat moderate to severe plaque psoriasis in adults.
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Drug Information:
Tremfya (guselkumab) is a monoclonal antibody that blocks a certain protein in the body that can cause inflammation and other immune responses. Tremfya is used to treat moderate to severe plaque psoriasis in adults. Tremfya may also be used for purposes not listed in this medication guide. Tremfya can weaken (suppress) your immune system, and you may get an infection more easily. Call your doctor if you have signs of infection such as fever, chills, body aches, weight loss, severe diarrhea, stomach cramps, pain or burning when you urinate, cough (may contain blood or mucus), shortness of breath, or skin sores that look different from psoriasis. Learn more

Tremfya Side Effects

Tremfya Side Effects

Note: This document contains side effect information about guselkumab. Some of the dosage forms listed on this page may not apply to the brand name Tremfya.

For the Consumer

Applies to guselkumab: subcutaneous solution

Along with its needed effects, guselkumab (the active ingredient contained in Tremfya) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking guselkumab:

More common

  • Body aches or pain
  • chills
  • cough
  • difficulty in breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness

Less Common

  • Burning or stinging of the skin
  • diarrhea
  • itching in the genital or other skin areas
  • loss of appetite
  • nausea
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • scaling
  • stomach pain


  • White patches in the mouth or throat or on the tongue

Some side effects of guselkumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • difficulty in moving
  • muscle pain or stiffness
  • pain in the joints


  • Headache, severe and throbbing
  • hives or welts
  • itching, skin rash
  • redness of the skin

For Healthcare Professionals

Applies to guselkumab: subcutaneous solution


Very common (10% or more): Infections (23%)

Common (1% to 10%): Tinea infections, herpes simplex infections, immunogenicity


Common (1% to 10%): Injection site reactions (e.g., injection site erythema, bruising, hematoma, hemorrhage, swelling, edema, pruritus, pain, discoloration, induration, inflammation, urticaria)


Common (1% to 10%): Arthralgia


Common (1% to 10%): Elevated liver enzymes


Very common (10% or more): Respiratory tract infection (e.g., nasopharyngitis, upper respiratory tract infection, pharyngitis, viral upper respiratory tract infection) (14%)

Nervous system

Common (1% to 10%): Headache


Common (1% to 10%): Diarrhea, gastroenteritis (including viral gastroenteritis)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tremfya