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Trelegy ellipta

Generic Name: fluticasone, umeclidinium, and vilanterol (floo TIK a sone, ue ME kli DIN ee um, and vye LAN ter ol)
Brand Names: Trelegy Ellipta
Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) is an inhalation powder used to treat COPD. Includes Trelegy Ellipta side effects, interactions and indications.
  • Prescription Settings

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Drug Information:
Trelegy Ellipta is an inhalation powder containing a combination of fluticasone, umeclidinium, and vilanterol. Fluticasone is a steroid that prevents the release of substances in the body that cause inflammation. Umeclidinium is an anticholinergic. Vilanterol is a bronchodilator. These medications work by relaxing muscles in the airways to improve breathing. Trelegy Ellipta is used to improve symptoms and prevent bronchospasm in adults with COPD (chronic obstructive pulmonary disease), including bronchitis and emphysema. Learn more

Trelegy ellipta Side Effects

Trelegy Ellipta Side Effects

Note: This document contains side effect information about fluticasone / umeclidinium / vilanterol. Some of the dosage forms listed on this page may not apply to the brand name Trelegy Ellipta.

For the Consumer

Applies to fluticasone / umeclidinium / vilanterol: inhalation powder


Inhalation route (Powder)

Asthma-related DeathLong-acting beta(2)-adrenergic agonists (LABA), such as vilanterol, one of the active ingredients in fluticasone furoate/umeclidinium/vilanterol oral inhalation powder, increase the risk of asthma-related death. Data from a large placebo-controlled U.S. trial that compared the safety of another LABA (salmeterol) with placebo added to usual asthma therapy showed an increase in asthma-related deaths in subjects receiving salmeterol. This finding with salmeterol is considered a class effect of LABA.The safety and efficacy of fluticasone furoate/umeclidinium/vilanterol oral inhalation powder in patients with asthma have not been established. Fluticasone furoate/umeclidinium/vilanterol oral inhalation powder is not indicated for the treatment of asthma.

Along with its needed effects, fluticasone / umeclidinium / vilanterol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluticasone / umeclidinium / vilanterol:

Less common

  • Cough
  • diarrhea
  • loss of appetite
  • nausea
  • pain in the nose and mouth
  • stomach pain
  • weakness

Some side effects of fluticasone / umeclidinium / vilanterol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Back pain
  • change in taste
  • headache
  • loss of taste

For Healthcare Professionals

Applies to fluticasone / umeclidinium / vilanterol: inhalation powder


Common (1% to 10%): Oropharyngeal pain, diarrhea, gastroenteritis


Common (1% to 10%): Back pain


Common (1% to 10%): Cough

Nervous system

Common (1% to 10%): Headache, dysgeusia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Trelegy Ellipta