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Generic Name: ethionamide (ETH eye ON a mide)
Brand Name: Trecator
Physician reviewed Trecator patient information - includes Trecator description, dosage and directions.
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Drug Information:
Trecator is an antibiotic that fights bacteria. Trecator is used to treat tuberculosis (TB). This medicine must be given in combination with other tuberculosis medications and it should not be used alone. Trecator may also be used for purposes not listed in this medication guide. You should not use Trecator if you have severe liver disease. You should not use Trecator if you are allergic to it, or if you have: severe liver disease. To make sure Trecator is safe for you, tell your doctor if you have: Learn more

Trecator Side Effects

Trecator Side Effects

Note: This document contains side effect information about ethionamide. Some of the dosage forms listed on this page may not apply to the brand name Trecator.

For the Consumer

Applies to ethionamide: oral tablet

Along with its needed effects, ethionamide (the active ingredient contained in Trecator) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ethionamide:

Less common

  • Clumsiness or unsteadiness
  • confusion
  • mental depression
  • numbness, tingling, burning, or pain in the hands and feet
  • yellow eyes or skin


  • Blindness or vision changes
  • blue-yellow color blindness
  • blurred vision or loss of vision, with or without eye pain
  • burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
  • changes in menstrual periods
  • coldness
  • decreased sexual ability (in males)
  • decreased vision
  • difficulty in concentrating
  • dry, puffy skin
  • fast heartbeat
  • fever
  • hives, itching, or rash
  • hoarseness
  • increased hunger
  • increased sensitivity of the skin to sunlight
  • irritation
  • joint pain, stiffness, or swelling
  • redness or other discoloration of the skin
  • severe sunburn
  • shakiness
  • swelling of the eyelids, face, lips, hands, or feet
  • swelling of the front part of the neck
  • tightness in the chest
  • troubled breathing or swallowing
  • weakness in the hands or feet
  • weight gain

Incidence not known

  • Chills
  • cold sweats
  • coma
  • cool, pale skin
  • dark urine
  • dizziness
  • general tiredness and weakness
  • headache
  • light-colored stools
  • nausea and vomiting
  • nightmares
  • seizures
  • slurred speech
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Some side effects of ethionamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • diarrhea
  • increased watering of the mouth
  • loss of appetite
  • metallic taste
  • swelling or inflammation of the mouth
  • weight loss

Incidence not known

  • Blemishes on the skin
  • decreased interest in sexual intercourse
  • enlargement of the breasts (in males)
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • pimples

For Healthcare Professionals

Applies to ethionamide: oral tablet


The most commonly reported side effects included abdominal pain, diarrhea, nausea, and vomiting.


Very common (10% or more): Adverse gastrointestinal effects (up to 50%)

Common (1% to 10%): Abdominal pain, diarrhea, excessive salivation, gastrointestinal disturbances, nausea, stomatitis, vomiting

Approximately 50% of patients are unable to tolerate 1 gram (as a single dose).


Common (1% to 10%): Anorexia, weight loss

Rare (0.01% to 0.1%): Pellagra-like syndrome

Frequency not reported: Hypoglycemia

Nervous system

Common (1% to 10%): Metallic taste

Rare (0.01% to 0.1%): Neurotoxic effects, peripheral neuritis

Frequency not reported: Dizziness, drowsiness, headache


Rare (0.01% to 0.1%): Blurred vision, diplopia, optic neuritis


Rare (0.01% to 0.1%): Photosensitivity, rash

Frequency not reported: Acne


Rare (0.01% to 0.1%): Purpura, thrombocytopenia


Rare (0.01% to 0.1%): Hypersensitivity reactions


Frequency not reported: Hepatitis with/without jaundice, transient ALT increases, transient AST increases, transient serum bilirubin increases


Frequency not reported: Mental depression, psychotic disturbances, restlessness


Frequency not reported: Gynecomastia, hypothyroidism


Frequency not reported: Postural hypotension


Frequency not reported: Impotence

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Trecator