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Generic Name: tobramycin ophthalmic (TOE bra MYE sin off THAL mik)
Brand Name: Tobrasol, Tobrex
Physician reviewed Tobrex patient information - includes Tobrex description, dosage and directions.
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Drug Information:
Tobramycin is an antibiotic that fights bacteria. Tobrex (for the eyes) is used to treat bacterial infections of the eyes. Tobrex will not treat a viral or fungal infection of the eye. Tobrex is for use in treating only bacterial infections. Tobrex may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. You should not use Tobrex if you are allergic to tobramycin, or if you have: Learn more

Tobrex Side Effects

Tobrex Side Effects

Note: This document contains side effect information about tobramycin ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Tobrex.

For the Consumer

Applies to tobramycin ophthalmic: ophthalmic ointment, ophthalmic solution

Along with its needed effects, tobramycin ophthalmic (the active ingredient contained in Tobrex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tobramycin ophthalmic:

Less common

  • Itching, redness, swelling, or other sign of eye or eyelid irritation not present before use of this medicine

Symptoms of overdose

  • Increased watering of the eyes
  • itching, redness, or swelling of the eyes or eyelids
  • painful irritation of the clear front part of the eye

Some side effects of tobramycin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Burning or stinging of the eyes

Eye ointments usually cause your vision to blur for a few minutes after application.

For Healthcare Professionals

Applies to tobramycin ophthalmic: ophthalmic ointment, ophthalmic solution


The most frequently reported side effects included localized ocular toxicity and hypersensitivity reactions.


Common (1% to 10%): Conjunctival erythema, eye itching, lacrimation, lid itching, lid swelling, ocular discomfort, ocular hyperemia, punctate keratitis

Uncommon (0.1% to 1%): Blurred vision, conjunctival disorder, dry eye, eye discharge, eye pain, eye pruritus, eyelid disorder, eyelid edema, eyelid erythema, keratitis, lacrimation increased, visual impairment

Frequency not reported: Burning of the eyes, eye allergy, eye irritation, eyelid pruritus, stinging of the eyes


Common (1% to 10%): Hypersensitivity reactions

Frequency not reported: Anaphylactic reaction


Uncommon (0.1% to 1%): Dermatitis, dry skin, leukoderma, madarosis, pruritus, urticaria

Frequency not reported: Erythema multiforme, rash, Stevens-Johnson syndrome


Frequency not reported: Increased systemic toxicity

The risk of systemic toxicity is higher in patients receiving systemic aminoglycosides concurrently; total serum concentration monitoring should be considered in this population.


Localized ocular toxicity included conjunctival erythema, eye itching, lacrimation, lid itching, lid swelling, ocular hyperemia, and punctate keratitis.

Common (1% to 10%): Localized ocular toxicity

Uncommon (0.1% to 1%): Corneal abrasion, foreign body sensation in eyes

Nervous system

Uncommon (0.1% to 1%): Headache

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tobrex