Note: This document contains side effect information about fibrin sealant topical. Some of the dosage forms listed on this page may not apply to the brand name Tisseel.
Applies to fibrin sealant topical: solution
Other dosage forms:
Along with its needed effects, fibrin sealant topical (the active ingredient contained in Tisseel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking fibrin sealant topical:
Incidence not known
Some side effects of fibrin sealant topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to fibrin sealant topical: topical kit, topical solution
General side effects have been reported including rare reports of serious adverse events such as paralysis and other compressive complications possibly related to the use of fibrin sealant in combination with resorbable hemostatic agents. There have also been rare reports of fatalities following the misadministration of topical thrombin.
Hypersensitivity side effects such as anaphylactic and anaphylactoid reactions including shock have been reported rarely.
Cardiovascular side effects including tachycardia, bradycardia, hypotension, and thromboembolic complications have been reported rarely.
Respiratory side effects including severe dyspnea have been reported rarely.
Dermatologic side effects including flush, urticaria, and pruritus have been reported rarely.
Gastrointestinal side effects including nausea have been reported rarely.
A D-dimer is a fragment produced during the degradation of a clot. Postoperatively increased D-dimers may result at least partly from the degradation of fibrin sealant.
Other side effects including increased D-dimer levels have been reported in a clinical study on cardiovascular surgery, but did not exceed values reported in the literature occurring after this type of surgery.
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Tisseel