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Theochron

Generic Name: Theophylline Sustained-Release Tablets (thee OFF i lin)
Brand Name: Theochron
Easy-to-read patient leaflet for Theochron. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This is not a list of all drugs or health problems that interact with Theochron (theophylline sustained-release tablets). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Theochron (theophylline sustained-release tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Theochron (theophylline sustained-release tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Theochron Side Effects

Theochron Side Effects

Note: This document contains side effect information about theophylline. Some of the dosage forms listed on this page may not apply to the brand name Theochron.

For the Consumer

Applies to theophylline: oral capsule extended release 24 hr, oral elixir, oral solution, oral tablet extended release, oral tablet extended release 12 hr, oral tablet extended release 24 hr

Other dosage forms:

  • intravenous solution

Along with its needed effects, theophylline (the active ingredient contained in Theochron) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking theophylline:

Incidence not known

  • Chest pain or discomfort
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • increase in urine volume
  • lightheadedness
  • persistent vomiting
  • pounding or rapid pulse
  • seizures
  • shakiness

Get emergency help immediately if any of the following symptoms of overdose occur while taking theophylline:

Symptoms of overdose

  • Abdominal or stomach pain
  • blurred vision
  • confusion
  • confusion about identity, place, and time
  • dark-colored urine
  • decrease in frequency of urination
  • decreased urine
  • diarrhea
  • difficulty in passing urine (dribbling)
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back, or neck
  • painful urination
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds

Some side effects of theophylline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Headache
  • irritability
  • restlessness
  • sleeplessness
  • trouble sleeping
  • unable to sleep

For Healthcare Professionals

Applies to theophylline: compounding powder, intravenous solution, oral capsule, oral capsule extended release, oral elixir, oral solution, oral syrup, oral tablet, oral tablet extended release

General

Adverse events are generally mild when theophylline (the active ingredient contained in Theochron) levels are under 20 mcg/mL; the most common adverse events were caffeine-like adverse effects like nausea, vomiting, headache, and insomnia.

When theophylline concentrations exceed 20 mcg/mL, many adverse effects may occur, including persistent vomiting, cardiac arrhythmias, and intractable seizures, which may be fatal.

Cardiovascular

Very common (10% or more): Sinus tachycardia (up to 100% in acute overdose, up to 100% with chronic overdose), ventricular arrhythmias with hemodynamic instability (14% in acute overdose, 40% with chronic overdose), other supraventricular tachycardias (21% in acute overdose, 14% with chronic overdose), ventricular premature beats (21% in acute overdose, 19% with chronic overdose), hypotension/shock (21% in acute overdose, 8% with chronic overdose), atrial fibrillation or flutter (1% in acute overdose, 12% with chronic overdose)

Common (1% to 10%): Multifocal atrial tachycardia (2% with chronic overdose)

Frequency not reported: Cardiac arrhythmias (at serum concentrations over 20 mcg/mL), multifocal atrial tachycardia and flutter (at serum concentrations 15 mcg/mL and over in hypoxia secondary to COPD patients)

Nervous system

-A few seizures have been reported in patients with underlying neurological disease or in elderly patients with serum theophylline (the active ingredient contained in Theochron) under 20 mcg/mL.

-Seizures in elderly patients with serum theophylline under 20 mcg/mL may be due to decreased protein binding causing higher unbound (pharmacologically active) theophylline levels.

-Seizures in patients with serum theophylline under 20 mcg/mL were generally milder (than those from overdose) such as being transient, not requiring anticonvulsants, and no neurological residuals.

-Consider the possibility of non-convulsive status epilepticus in patients with abnormal central nervous system function and theophylline use.

Gastrointestinal

Very common (10% or more): Vomiting (93% in acute overdose, 61% with chronic overdose), abdominal pain (21% in acute overdose, 12% with chronic overdose), diarrhea (14% with chronic overdose)

Common (1% to 10%): Hematemesis (2% with chronic overdose)

Frequency not reported: Nausea, vomiting, persistent vomiting (at serum concentrations over 20 mcg/mL), diarrhea

Nervous system

Very common (10% or more): Tremors (38% in acute overdose, 16% with chronic overdose), seizures (14% in acute overdose, 14% with chronic overdose)

Frequency not reported: Headache, intractable seizures (at serum concentrations over 20 mcg/mL), seizures

Metabolic

Very common (10% or more): Hyperglycemia (98% in acute overdose, 18% with chronic overdose), hypokalemia (85% in acute overdose, 44% with chronic overdose), acid/base disturbance (34% in acute overdose, 9% with chronic overdose)

Frequency not reported: Hypercalcemia (in a hyperthyroid patient), hypervolemia

Psychiatric

Very common (10% or more): Nervousness (64% in acute overdose, 21% with chronic overdose), disorientation (7% in acute overdose, 12% with chronic overdose)

Frequency not reported: Insomnia, irritability, restlessness

Musculoskeletal

Uncommon (0.1% to 1%): Rhabdomyolysis (7% in acute overdose)

Frequency not reported: Fine skeletal muscle tremors

Other

Very common (10% or more): Death (21% in acute overdose, 10% with chronic overdose)

Frequency not reported: Febrile response

Genitourinary

Frequency not reported: Transient diuresis

Local

Frequency not reported: Infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Theochron