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Generic Name: ceftaroline (SEF ta ROE leen)
Brand Names: Teflaro
Teflaro (ceftaroline) is used to treat acute bacterial skin and skin infections and community acquired bacterial pneumonia. Includes Teflaro side effects, interactions and indications.
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Drug Information:
Teflaro (ceftaroline) is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. Teflaro is used to treat skin infections or pneumonia caused by bacteria. Teflaro may also be used for purposes not listed in this medication guide. You should not use Teflaro if you are allergic to ceftaroline or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others. Tell your doctor if you are allergic to any drugs, especially penicillins or other antibiotics. Learn more

Teflaro Side Effects

Teflaro Side Effects

Note: This document contains side effect information about ceftaroline. Some of the dosage forms listed on this page may not apply to the brand name Teflaro.

In Summary

Common side effects of Teflaro include: positive direct coombs test. Other side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ceftaroline: intravenous powder for solution

Along with its needed effects, ceftaroline (the active ingredient contained in Teflaro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftaroline:

More common

  • Back, leg, or stomach pains
  • bleeding gums
  • chills
  • dark urine
  • difficulty with breathing
  • fever
  • general body swelling
  • headache
  • loss of appetite
  • nausea or vomiting
  • nosebleeds
  • pale skin
  • sore throat
  • unusual tiredness or weakness
  • yellowing of the eyes or skin

Less common

  • Abdominal or stomach tenderness
  • black, tarry stools
  • blood in the urine or stools
  • bluish color
  • changes in skin color
  • chest pain or discomfort
  • confusion
  • convulsions
  • cough
  • decreased frequency or amount of urine
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • fast, irregular, pounding, or racing heartbeat or pulse
  • general tiredness and weakness
  • hives or itching
  • increased blood pressure
  • increased thirst
  • light-colored stools
  • lightheadedness, dizziness, or fainting
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe abdominal or stomach cramps and pain
  • skin itching, rash, or redness
  • slow or irregular heartbeat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, throat, fingers, or lower legs
  • swollen glands
  • tenderness
  • tightness in the chest
  • troubled breathing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • watery and severe diarrhea, which may also be bloody
  • weakness or heaviness of the legs
  • weight gain

Some side effects of ceftaroline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Blurred vision
  • difficulty having a bowel movement (stool)
  • flushed, dry skin fruit-like breath odor
  • increased hunger
  • increased urination
  • sweating
  • unexplained weight loss
  • welts

For Healthcare Professionals

Applies to ceftaroline: intravenous powder for injection


The most common side effects reported in adults using this drug were diarrhea, headache, nausea, pruritus, and rash.


Common (1% to 10%): Diarrhea, nausea, constipation, vomiting, abdominal pain

Uncommon (0.1% to 1%): Clostridium difficile colitis

Frequency not reported: C difficile-associated diarrhea, dyspepsia


Common (1% to 10%): Rash, pruritus, generalized pruritus

Uncommon (0.1% to 1%): Urticaria

In clinical trials using this drug every 12 hours or every 8 hours, rash was common; however, in a subgroup of Asian patients using this drug every 8 hours, rash was very common (18.5%).


Common (1% to 10%): Hypokalemia

Frequency not reported: Decreased appetite, hyperglycemia, hyperkalemia


Common (1% to 10%): Phlebitis, hypertension, increased blood pressure

Frequency not reported: Bradycardia, palpitations


Common (1% to 10%): Increased transaminases, increased ALT

Frequency not reported: Abnormal hepatic function, hepatitis, increased AST


Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported with beta-lactam antibacterials.

Uncommon (0.1% to 1%): Hypersensitivity (e.g., urticaria, lip and face swelling), anaphylaxis


Uncommon (0.1% to 1%): Increased blood creatinine

Frequency not reported: Renal failure


In clinical trials, direct antiglobulin test seroconversion was reported in 10.7% of adult patients using this drug every 12 hours (600 mg infused over 1 hour every 12 hours) and in 32.3% of those using this drug every 8 hours (600 mg infused over 2 hours every 8 hours). Seroconversion from negative to positive direct Coombs test result was reported in 17.9% of children using this drug.

Agranulocytosis and leukopenia have also been reported during postmarketing experience.

Very common (10% or more): Direct antiglobulin test/Coombs test seroconversion (up to 32.3%), positive direct Coombs test

Uncommon (0.1% to 1%): Anemia, leukopenia, neutropenia, thrombocytopenia, prolonged prothrombin time, prolonged activated partial thromboplastin time, increased INR

Rare (0.01% to 0.1%): Agranulocytosis

Frequency not reported: Eosinophilia

Nervous system

Common (1% to 10%): Headache, dizziness

Frequency not reported: Convulsion


Common (1% to 10%): Pyrexia, infusion site reactions (e.g., erythema, phlebitis, pain)

Frequency not reported: Asthenia


Frequency not reported: Urinary tract infection


Common (1% to 10%): Insomnia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Teflaro