Note: This document contains side effect information about ceftaroline. Some of the dosage forms listed on this page may not apply to the brand name Teflaro.
Common side effects of Teflaro include: positive direct coombs test. Other side effects include: diarrhea. See below for a comprehensive list of adverse effects.
Applies to ceftaroline: intravenous powder for solution
Along with its needed effects, ceftaroline (the active ingredient contained in Teflaro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftaroline:
Some side effects of ceftaroline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to ceftaroline: intravenous powder for injection
The most common side effects reported in adults using this drug were diarrhea, headache, nausea, pruritus, and rash.
Common (1% to 10%): Diarrhea, nausea, constipation, vomiting, abdominal pain
Uncommon (0.1% to 1%): Clostridium difficile colitis
Frequency not reported: C difficile-associated diarrhea, dyspepsia
Common (1% to 10%): Rash, pruritus, generalized pruritus
Uncommon (0.1% to 1%): Urticaria
In clinical trials using this drug every 12 hours or every 8 hours, rash was common; however, in a subgroup of Asian patients using this drug every 8 hours, rash was very common (18.5%).
Common (1% to 10%): Hypokalemia
Frequency not reported: Decreased appetite, hyperglycemia, hyperkalemia
Common (1% to 10%): Phlebitis, hypertension, increased blood pressure
Frequency not reported: Bradycardia, palpitations
Common (1% to 10%): Increased transaminases, increased ALT
Frequency not reported: Abnormal hepatic function, hepatitis, increased AST
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported with beta-lactam antibacterials.
Uncommon (0.1% to 1%): Hypersensitivity (e.g., urticaria, lip and face swelling), anaphylaxis
Uncommon (0.1% to 1%): Increased blood creatinine
Frequency not reported: Renal failure
In clinical trials, direct antiglobulin test seroconversion was reported in 10.7% of adult patients using this drug every 12 hours (600 mg infused over 1 hour every 12 hours) and in 32.3% of those using this drug every 8 hours (600 mg infused over 2 hours every 8 hours). Seroconversion from negative to positive direct Coombs test result was reported in 17.9% of children using this drug.
Agranulocytosis and leukopenia have also been reported during postmarketing experience.
Very common (10% or more): Direct antiglobulin test/Coombs test seroconversion (up to 32.3%), positive direct Coombs test
Uncommon (0.1% to 1%): Anemia, leukopenia, neutropenia, thrombocytopenia, prolonged prothrombin time, prolonged activated partial thromboplastin time, increased INR
Rare (0.01% to 0.1%): Agranulocytosis
Frequency not reported: Eosinophilia
Common (1% to 10%): Headache, dizziness
Frequency not reported: Convulsion
Common (1% to 10%): Pyrexia, infusion site reactions (e.g., erythema, phlebitis, pain)
Frequency not reported: Asthenia
Frequency not reported: Urinary tract infection
Common (1% to 10%): Insomnia
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Teflaro