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Tarka

Generic Name: trandolapril and verapamil (tran DOL a pril and ver AP a mil)
Brand Name: Tarka
Physician reviewed Tarka patient information - includes Tarka description, dosage and directions.
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Drug Information:
Trandolapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Tarka is a combination medicine used to treat high blood pressure (hypertension). Tarka may also be used for purposes not listed in this medication guide. Do not use if you are pregnant. Stop using Tarka and tell your doctor right away if you become pregnant. You should not use this medicine if you have a heart rhythm disorder, low blood pressure, or a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker). Do not take Tarka within 36 hours before or after taking medicine that contains sacubitril (such as Entresto). Learn more

Tarka Side Effects

Tarka Side Effects

Note: This document contains side effect information about trandolapril / verapamil. Some of the dosage forms listed on this page may not apply to the brand name Tarka.

In Summary

Common side effects of Tarka include: sinus bradycardia. Other side effects include: bradycardia, first degree atrioventricular block, and second degree atrioventricular block. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trandolapril / verapamil: oral tablet extended release

Warning

Oral route (Tablet, Extended Release)

Discontinue treatment with trandolapril/verapamil hydrochloride as soon as possible when pregnancy is detected, since fetal toxicity, including injury and death to the developing fetus, can be caused by drugs that act directly on the renin-angiotensin system.

Along with its needed effects, trandolapril / verapamil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trandolapril / verapamil:

Rare

  • Chest pain
  • chills
  • cough (with mucus)
  • dark urine
  • fever
  • general feeling of discomfort or illness
  • lightheadedness or fainting
  • pain in the right side of the abdomen or stomach
  • slow heartbeat
  • sore throat
  • swelling of the face, mouth, hands, or feet
  • trouble in swallowing or breathing (sudden) accompanied by hoarseness
  • yellow eyes or skin

Some side effects of trandolapril / verapamil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • Constipation
  • cough (dry, continuous)
  • diarrhea
  • dizziness
  • itching
  • joint pain or pain in the arms or legs
  • nausea
  • unusual tiredness

For Healthcare Professionals

Applies to trandolapril / verapamil: oral tablet extended release

General

The most common adverse reactions were headache, upper respiratory tract infection, cough, atrioventricular block first degree, constipation, and dizziness.

Respiratory

Common (1% to 10%): Upper respiratory tract infection, cough, dyspnea, bronchitis, upper respiratory tract congestion

Frequency not reported: Epistaxis

Verapamil:

Frequency not reported: Pulmonary edema

Other

Common (1% to 10%): Asthenia/weakness, chest pain, edema, fatigue

Frequency not reported: Malaise

Verapamil:

Frequency not reported: Gynecomastia

Gastrointestinal

Common (1% to 10%): Constipation, nausea, diarrhea

Frequency not reported: Dyspepsia, dry mouth

Trandolapril:

Frequency not reported: Pancreatitis

Verapamil:

Frequency not reported: Gingival hyperplasia, reversible nonobstructive paralytic ileus

Musculoskeletal

Common (1% to 10%): Pain back, pain extremity, pain joint

Frequency not reported: Arthralgias/myalgias

Cardiovascular

Common (1% to 10%): Atrioventricular (AV) block first degree, bradycardia

Uncommon (0.1% to 1%): Hypotension

Frequency not reported: Angina, AV block second degree, bundle branch block, flushing, myocardial infarction, palpitation, premature ventricular contraction, nonspecific ST-T changes, tachycardia

Verapamil:

Frequency not reported: Congestive heart failure, AV block third degree, AV dissociation, claudication, vasculitis

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Near syncope

Frequency not reported: Drowsiness, hypesthesia, loss of balance, paresthesia, vertigo, tinnitus

Verapamil:

Frequency not reported: Syncope, cerebrovascular accident, shakiness, somnolence

Postmarketing reports: Tetraparesis

There has been one postmarketing report of paralysis (tetraparesis) with verapamil, which may have been caused by concomitant use of colchicine.

Renal

Common (1% to 10%): Creatinine increased

Uncommon (0.1% to 1%): BUN increased

Metabolic

Common (1% to 10%): Hyperlipidemia

Frequency not reported: Gout, uric acid increased, hyperkalemia, hyponatremia

Hepatic

Common (1% to 10%): Liver enzymes increased

Frequency not reported: Serum bilirubin increased

Immunologic

Common (1% to 10%): Influenza

Dermatologic

Uncommon (0.1% to 1%): Angioedema

Frequency not reported: Pruritus, rash

Verapamil:

Frequency not reported: Purpura, ecchymosis, exanthema, hair loss, hyperkeratosis, maculae, Stevens-Johnson syndrome, erythema multiform

Genitourinary

Frequency not reported: Impotence, endometriosis, hematuria, nocturia, polyuria, proteinuria

Verapamil:

Frequency not reported: Urination increased, menstruation spotty

Hematologic

Frequency not reported: Leukocytes decreased, neutrophils decreased, white blood cells low, neutrophils low, lymphocytes low, platelets low

Psychiatric

Frequency not reported: Insomnia, anxiety, mentation abnormal

Trandolapril:

Frequency not reported: Libido decreased

Verapamil:

Frequency not reported: Confusion, psychotic symptoms

Ocular

Frequency not reported: Vision blurred

Endocrine

Verapamil:

Frequency not reported: Galactorrhea/hyperprolactinemia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tarka