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Generic Name: lanadelumab-flyo (LAN a DEL ue mab)
Brand Names: Takhzyro
Takhzyro (lanadelumab-flyo) is used to treat hereditary angioedema. Includes Takhzyro side effects, interactions and indications.
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Drug Information:
Takhzyro (lanadelumab-flyo) is a monoclonal antibody that works by reducing the activity of an enzyme that is uncontrolled in people with hereditary angioedema (a rare genetic immune system disorder). Takhzyro is used to prevent attacks of hereditary angioedema (HAE) in people who are at least 12 years old. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. You should not use Takhzyro if you are allergic to lanadelumab. Learn more

Takhzyro Side Effects

Takhzyro Side Effects

Note: This document contains side effect information about lanadelumab. Some of the dosage forms listed on this page may not apply to the brand name Takhzyro.

For the Consumer

Applies to lanadelumab: subcutaneous solution

Along with its needed effects, lanadelumab (the active ingredient contained in Takhzyro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lanadelumab:

More common

  • Rash

Less common

  • Fast heartbeat
  • fever
  • hives, itching
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing

Some side effects of lanadelumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • body aches or pain
  • chills
  • cough
  • difficulty in moving
  • dizziness
  • ear congestion
  • headache
  • loss of voice
  • muscle ache, cramps, pain, or stiffness
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness

Less common

  • Diarrhea

For Healthcare Professionals

Applies to lanadelumab: subcutaneous solution


The most common adverse reactions were injection site reactions, upper respiratory infection, headache, rash, myalgia, dizziness, and diarrhea.


Very common (10% or more): Upper respiratory infection (up to 44%)

Frequency not reported: Viral upper respiratory infection

Nervous system

Very common (10% or more): Headache (up to 33%), dizziness (up to 10%)

Frequency not reported: Tension headache, sinus headache


Very common (10% or more): Anti-drug antibody (ADA)-positive sample during treatment with this drug (12%)

Common (1% to 10%): Hypersensitivity


Very common (10% or more): Myalgia (up to 11%)


Very common (10% or more): Diarrhea (up to 11%)


Common (1% to 10%): ALT increased, AST increased, ALT or AST greater than 8 times the upper limit of normal


Very common (10% or more): Injection site reactions (up to 56%)

Frequency not reported: Pain, erythema, bruising, hematoma, hemorrhage, pruritus, swelling, induration, paresthesia, warmth, edema, rash


Very common (10% or more): Rash (up to 10%)

Frequency not reported: Maculopapular rash, erythematous rash

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Takhzyro