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Generic Name: osimertinib (OH sim ER ti nib)
Brand Names: Tagrisso
Tagrisso (osimertinib) is used to treat EGFR T790M mutation-positive non-small cell lung cancer. Includes Tagrisso side effects, interactions and indications.
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Drug Information:
Tagrisso (osimertinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Tagrisso is used to treat a certain type of non-small cell lung cancer. Osimertinib is used only if your tumor has a specific genetic marker, for which your doctor will test. Tagrisso is usually given after other treatments have failed. Tagrisso may cause lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your doctor right away if you have any new or worsening lung symptoms, including trouble breathing, shortness of breath, cough, or fever. Learn more

Tagrisso Side Effects

Tagrisso Side Effects

Note: This document contains side effect information about osimertinib. Some of the dosage forms listed on this page may not apply to the brand name Tagrisso.

In Summary

Common side effects of Tagrisso include: cough. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to osimertinib: oral tablet

Along with its needed effects, osimertinib (the active ingredient contained in Tagrisso) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking osimertinib:

More common

  • Anxiety
  • cough
  • dizziness, lightheadedness, or fainting
  • eye or vision changes
  • fast, pounding, or uneven heartbeat
  • pain in the chest, groin, or legs, especially the calves
  • pain, redness, or swelling in the arm or leg
  • slurred speech
  • sudden loss of coordination
  • sudden, severe headache
  • sudden, severe weakness or numbness in the arm or leg
  • troubled breathing

Less common

  • Blurred vision
  • chills
  • fever
  • general feeling of discomfort or illness
  • inability to speak
  • seizures
  • sneezing
  • sore throat
  • sudden, severe weakness on one side of the body
  • temporary blindness
  • thickening of bronchial secretions


  • Eye redness, irritation, or pain

Some side effects of osimertinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • changes in the fingernails or toenails, including brittleness, inflammation, pain, redness, tenderness, separation from nail bed, or shedding of nails
  • constipation
  • decreased appetite
  • diarrhea
  • headache
  • nausea
  • skin rash, dryness, or itching
  • swelling or inflammation of the mouth
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to osimertinib: oral tablet


Very common (10% or more): Lymphopenia (63%), thrombocytopenia (54%), anemia (44%), neutropenia (33%)


Very common (10% or more): Diarrhea (42%), nausea (17%), decreased appetite (16%), constipation (15%), stomatitis (12%), vomiting (11%)


Very common (10% or more): Rash (e.g., generalized, erythematous, macular, maculopapular, papular, pustular), erythema, folliculitis, acne, dermatitis, acneiform dermatitis (58%), dry skin (e.g., eczema, skin fissures, xerosis) (36%), nail toxicity (e.g., nail and nail bed disorders, nail bed inflammation, nail bed tenderness, nail discoloration, nail dystrophy, nail infection, nail ridging, onychoclasis, onycholysis, onychomadesis, paronychia) (35%), pruritus (17%)


Very common (10% or more): Hyponatremia (26%), hypermagnesemia (20%)


Very common (10% or more): Eye disorders (e.g., dry eye, blurred vision, keratitis, cataract, eye irritation, blepharitis, eye pain, increased lacrimation, vitreous floaters) (18%)

Uncommon (0.1% to 1%): Other ocular toxicities


Very common (10% or more): Cough (17%), dyspnea (13%)

Common (1% to 10%): ILD/pneumonitis, pneumonia


Very common (10% or more): Fatigue (22%)


Very common (10% or more): Back pain (13%)

Nervous system

Very common (10% or more): Headache (10%)

Common (1% to 10%): CVA/cerebral hemorrhage


Common (1% to 10%): Cardiomyopathy, venous thromboembolism (includes deep vein thrombosis, jugular venous thrombosis, and pulmonary embolism)

Frequency not reported: QTc interval prolongation

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tagrisso