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Tafinlar

Generic Name: dabrafenib (da bRAF e nib)
Brand Names: Tafinlar
Tafinlar is used to treat metastatic melanoma (skin cancer that has spread to other parts of the body). Learn about side effects, interactions and indications.
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Drug Information:
Tafinlar (dabrafenib) is a cancer medication that interferes with the growth and spread of cancer cells in the body. Tafinlar is used alone or in combination with another medicine called trametinib (Mekinist) to treat certain types of cancer in people who have a "BRAF" gene mutation. Tafinlar is for use in treating: melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body, or to prevent melanoma from coming back after surgery; non-small cell lung cancer that has spread to other parts of the body; or Learn more

Tafinlar Side Effects

Tafinlar Side Effects

Note: This document contains side effect information about dabrafenib. Some of the dosage forms listed on this page may not apply to the brand name Tafinlar.

In Summary

Common side effects of Tafinlar include: squamous cell carcinoma, fever, and hyperglycemia. Other side effects include: keratoacanthoma. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dabrafenib: oral capsule

Along with its needed effects, dabrafenib (the active ingredient contained in Tafinlar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dabrafenib:

More common

  • Bleeding gums
  • bloody or cloudy urine
  • blurred vision
  • coughing up blood
  • difficulty in breathing or swallowing
  • dizziness
  • dry mouth
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • greatly decreased frequency of urination or amount of urine
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • lump or growth on the skin
  • nausea
  • nosebleed
  • prolonged bleeding from cuts
  • red or dark brown urine
  • red or black, tarry stools
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • skin blisters
  • skin rash
  • stomach pain
  • sweating
  • swelling of the feet or lower legs
  • tingling of the hands and feet
  • ulceration of the skin
  • unable to move
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting

Less common

  • Blurred vision or other change in vision
  • change in color vision
  • difficulty seeing at night
  • eye pain
  • increased sensitivity of the eyes to sunlight
  • redness of the eye
  • tearing

Some side effects of dabrafenib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • constipation
  • cough
  • difficulty having a bowel movement
  • difficulty with moving
  • fast heartbeat
  • hair loss or thinning of the hair
  • headache
  • indigestion
  • loss of appetite
  • muscle ache, pain, or stiffness
  • pain in the joints
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • sore throat
  • stuffy or runny nose
  • yellow eyes or skin

For Healthcare Professionals

Applies to dabrafenib: oral capsule

Metabolic

Very common (10% or more): Hyperglycemia (71%), hypophosphatemia (38%), decreased appetite (29%), hyponatremia (57%)

Common (1% to 10%): Dehydration

Hepatic

Very common (10% or more): Increased alkaline phosphatase (64%), increased AST (61%), increased ALT (38%)

Common (1% to 10%): Increased gamma-glutamyltransferase, hyperbilirubinemia

Other

Very common (10% or more): Pyrexia (55%), fatigue/asthenia/malaise (51%), chills (31%), edema (28%)

Common (1% to 10%): Influenza-like illness, mucosal inflammation

Hematologic

Very common (10% or more): Leukopenia (48%), anemia (46%), neutropenia (44%), lymphopenia (42%)

Common (1% to 10%): Thrombocytopenia

Gastrointestinal

Very common (10% or more): Nausea (45%), vomiting (33%), diarrhea (32%), constipation (13%), abdominal pain (11%)

Common (1% to 10%): Dry mouth, stomatitis

Uncommon (0.1% to 1%): Pancreatitis, gastrointestinal perforation, colitis

Dermatologic

Very common (10% or more): Hyperkeratosis (37%), rash (32%), dry skin (31%), alopecia (22%), palmar-plantar erythrodysesthesia syndrome (20%), pruritus, erythema

Common (1% to 10%): Actinic keratosis, skin lesion, photosensitivity reaction, cellulitis, folliculitis, paronychia, pustular rash, dermatitis acneiform, night sweats, hyperhidrosis, panniculitis, skin fissures

Uncommon (0.1% to 1%): Serious skin toxicity

Frequency not reported: Bullous rash

Nervous system

Very common (10% or more): Headache (32%), dizziness (11%)

Musculoskeletal

Very common (10% or more): Arthralgia (27%), myalgia (15%), pain in extremity (14%), back pain (12%), muscle spasms

Common (1% to 10%): Increased creatine phosphokinase

Uncommon (0.1% to 1%): Rhabdomyolysis

Oncologic

Very common (10% or more): Papilloma (27%)

Common (1% to 10%): Cutaneous squamous cell carcinoma/keratoacanthoma/Bowen's disease, basal cell carcinoma, seborrheic keratosis, acrochordon

Uncommon (0.1% to 1%): New primary melanoma

Cardiovascular

Very common (10% or more): Hemorrhage (23%), hypertension (22%)

Common (1% to 10%): Cardiomyopathy/decreased left ventricular ejection fraction, hypotension, lymphedema, bradycardia

Uncommon (0.1% to 1%): QT prolongation, cardiac failure

Frequency not reported: Myocarditis

Respiratory

Very common (10% or more): Cough (22%), dyspnea (20%), nasopharyngitis (12%)

Common (1% to 10%): Interstitial lung disease/pneumonitis

Frequency not reported: Respiratory distress

Renal

Very common (10% or more): Increased creatinine (21%)

Common (1% to 10%): Renal failure

Uncommon (0.1% to 1%): Acute renal failure, nephritis

Frequency not reported: Interstitial nephritis

Genitourinary

Very common (10% or more): Urinary tract infection

Ocular

Common (1% to 10%): Uveitis, blurred vision, vision impairment

Uncommon (0.1% to 1%): Chorioretinopathy, retinal detachment, periorbital edema

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Tafinlar