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Generic Name: betamethasone and calcipotriene (topical) (BAY ta METH a sone and KAL si poe TRYE een)
Brand Names: Enstilar, Taclonex, Taclonex Scalp
Taclonex is a combination of betamethasone and calcipotriene and is used to treat psoriasis vulgaris. Includes Taclonex side effects, interactions and indications.
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Drug Information:
Taclonex contains a combination of betamethasone and calcipotriene. Betamethasone is a steroid. It prevents the release of substances in the body that cause inflammation. Calcipotriene is a form of vitamin D. It works by decreasing the rate of skin cell reproduction. Taclonex topical (for the skin) is a combination medicine used to treat plaque psoriasis. Adults may use the suspension (liquid) form of this medicine on the skin or the scalp. The liquid may be used only on the scalp in children who are at least 12 years old. Learn more

Taclonex Side Effects

Taclonex Side Effects

Note: This document contains side effect information about betamethasone / calcipotriene topical. Some of the dosage forms listed on this page may not apply to the brand name Taclonex.

For the Consumer

Applies to betamethasone/calcipotriene topical: topical application foam, topical application ointment, topical application suspension

Along with its needed effects, betamethasone/calcipotriene topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betamethasone/calcipotriene topical:

Less common

  • Burning, itching, and pain in hairy areas
  • burning sensation of the skin
  • flushing or redness of the skin
  • itching skin
  • pus at the root of the hair
  • red, scaling, or crusted skin
  • scaly rash
  • skin irritation
  • thinning of the skin with easy bruising
  • unusually warm skin


  • Body aches or pain
  • chills
  • cough
  • darkening of the skin
  • diarrhea
  • difficulty with breathing
  • ear congestion
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • lightening of normal skin color
  • lightening of the treated areas of dark skin
  • loss of appetite
  • loss of voice
  • muscle aches and pains
  • nasal congestion
  • nausea
  • raised, dark red, or wart-like spots on skin
  • red, sore eyes
  • runny nose
  • shivering
  • sneezing
  • sore throat
  • spots on your skin that look like a blister or pimple
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
  • worsening of the psoriasis

Some side effects of betamethasone / calcipotriene topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Bruising
  • large, flat, blue, or purplish patches in the skin
  • pain


  • Blemishes on the skin
  • pimples

For Healthcare Professionals

Applies to betamethasone / calcipotriene topical: topical foam, topical ointment, topical suspension


Very common (10% or more): Pruritus (17%)

Common (1% to 10%): Skin exfoliation

Uncommon (0.1% to 1%): Skin infection, folliculitis, skin atrophy, exacerbation of psoriasis, dermatitis, erythema, rash (e.g., exfoliative, papular, pustular), purpura, ecchymosis, skin burning sensation, skin irritation

Rare (less than 0.1%): Furuncle, pustular psoriasis, skin striae, photosensitivity reaction, acne, dry skin

Nervous system

Very common (10% or more): Headache (16%)


Rare (less than 0.1%): Hypercalcemia, hyperglycemia


Very common (10% or more): Adrenal suppression (15%)

Rare (less than 0.1%): Cushing's syndrome


Rare (less than 0.1%): Hypersensitivity


Very common (10% or more): Nasopharyngitis (11%)

Common (1% to 10%): Upper respiratory tract infection


Uncommon (0.1% to 1%): Application site pigmentation changes, application site pain/burning


Frequency not reported: Vision blurred

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Taclonex