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Generic Name: trientine (TRYE en teen)
Brand Name: Syprine
Physician reviewed Syprine patient information - includes Syprine description, dosage and directions.
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Drug Information:
Syprine is a chelating (KEE-late-ing) agent. A chelating agent works by removing a heavy metal (such as lead, mercury, or copper) from the blood. Wilson's disease is a genetic metabolic defect that causes excess copper to build up in the body. Syprine is used to treat this inherited condition in people who cannot take penicillamine. Syprine may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Learn more

Syprine Side Effects

Syprine Side Effects

Note: This document contains side effect information about trientine. Some of the dosage forms listed on this page may not apply to the brand name Syprine.

For the Consumer

Applies to trientine: oral capsule

Along with its needed effects, trientine (the active ingredient contained in Syprine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking trientine:

More common

- Symptoms of anemia
  • Unusually pale skin
  • unusual tiredness


  • Fever
  • general feeling of discomfort, illness, or weakness
  • joint pain
  • skin rash, blisters, hives, or itching
  • swollen glands

Note: Signs of anemia are more likely to occur in children, menstruating women, and pregnant women, who usually need more iron than other patients. If these signs appear during trientine treatment, your doctor will need to do some tests.

For Healthcare Professionals

Applies to trientine: oral capsule

Nervous system

Frequency not reported: Myasthenia gravis


Frequency not reported: Nausea, duodenitis, severe colitis, heartburn, epigastric pain and tenderness, acute gastritis, aphthoid ulcers, abdominal pain, melena


Very rare (less than 0.01%): Anemia, hypochromic microcytic anemia


Frequency not reported: Systemic lupus erythematosus, dystonia, muscular spasm, cramps, muscle pain, rhabdomyolysis


Frequency not reported: Iron deficiency, anorexia


Frequency not reported: Skin rash, thickening/fissuring/flaking of the skin


Frequency not reported: Malaise, weakness

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Syprine