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Synera

Generic Name: lidocaine and tetracaine topical (LYE doe kane and TET ra kane TOP i kal)
Brand Names: Synera
Synera is used to numb the skin before certain medical procedures. Learn about side effects, interactions and indications.
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Drug Information:
Synera patches contain a combination of lidocaine and tetracaine. Lidocaine and tetracaine are local anesthetics (numbing medicines). They work by blocking nerve signals in your body. Synera patches are used to numb a small area of your skin. This can help prevent pain during certain medical procedures such as a skin biopsy, minor skin surgery, insertion of an intravenous (IV) needle, or other needle-stick procedures. Synera patches are also used to numb a skin area during minor cosmetic procedures such as a Botox injection, laser treatment, or tattoo removal. Learn more

Synera Side Effects

Synera Side Effects

Note: This document contains side effect information about lidocaine / tetracaine topical. Some of the dosage forms listed on this page may not apply to the brand name Synera.

For the Consumer

Applies to lidocaine/tetracaine topical: topical application cream, topical application patch extended release

Along with its needed effects, lidocaine/tetracaine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lidocaine/tetracaine topical:

More common

  • Flushing or redness of the skin
  • swelling
  • unusually warm skin

Less common

  • Blistering, burning, crusting, dryness, or flaking of the skin
  • change in the color of treated skin
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • rash

Rare

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • cough or hoarseness
  • fainting or loss of consciousness
  • fast or irregular breathing
  • fever or chills
  • hives or welts
  • lower back or side pain
  • painful or difficult urination
  • swelling of the eyes or eyelids
  • tightness in the chest or wheezing
  • trouble with breathing

Incidence not known

  • Blurred vision
  • chest pain or discomfort
  • cold, clammy, or pale skin
  • confusion
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fast, slow, or irregular heartbeat
  • feelings of coldness, heat, or numbness
  • irregular, fast or slow, or shallow breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • no breathing
  • noisy breathing
  • pale or blue lips, fingernails, or skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • slow heart rate
  • sweating
  • trembling or shaking of the hands or feet
  • twitching
  • unconsciousness
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking lidocaine / tetracaine topical:

Symptoms of overdose

  • Change in consciousness
  • fast, pounding, or irregular heartbeat or pulse
  • no blood pressure or pulse
  • stopping of heart

Some side effects of lidocaine / tetracaine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

  • Headache
  • nausea
  • sleepiness or unusual drowsiness
  • vomiting

Incidence not known

  • Continuing ringing or buzzing or other unexplained noise in the ears
  • depression
  • double vision
  • drowsiness
  • false or unusual sense of well-being
  • fear
  • hearing loss
  • nervousness

For Healthcare Professionals

Applies to lidocaine / tetracaine topical: topical cream, topical film

Local

Local side effects have included erythema , blanching, edema, or abnormal sensation at the site of treatment. The most common of the local reactions were erythema (71%), blanching (12%), and edema (12%). These reactions were generally mild, and resolved spontaneously soon after treatment.

Hypersensitivity

Hypersensitivity side effects have included allergic or anaphylactoid reactions to the active or inactive ingredients. They may be characterized by urticaria, angioedema, bronchospasm, and shock.

Nervous system

Nervous system side effects are unlikely with appropriate use of lidocaine-tetracaine topical. Potential side effect include CNS excitation and/or depression (light-headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold, or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest). Excitatory CNS reactions may be brief or not occur at all, in which case the first manifestation may be drowsiness developing into unconsciousness. Signs of CNS toxicity may start at plasma concentrations of lidocaine as low as 1000 ng/mL. The plasma concentrations at which tetracaine toxicity may occur are less well characterized; however, systemic toxicity with tetracaine is thought to occur with much lower plasma concentrations compared with lidocaine. The toxicity of co-administered local anesthetics is thought to be at least additive.

Cardiovascular

Cardiovascular side effects are unlikely with appropriate use of lidocaine-tetracaine topical. Potential side effects include bradycardia, hypotension and cardiovascular collapse leading to arrest.

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Synera