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Generic Name: naldemedine (nal DEM e deen)
Brand Names: Symproic
Symproic (naldemedine) is used to treat constipation caused by opioid pain medicine. Symproic is used in people who have been taking opioid pain medicine for at least 4 weeks, to treat chronic pain that is not caused by cancer.
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Drug Information:
Symproic (naldemedine) blocks certain effects of opioid medication. An opioid is sometimes called a narcotic. Symproic reduces constipation caused by opioid pain medicine used to treat severe chronic pain. Naldemedine works by treating constipation without reducing the pain-relieving effects of the narcotic. Symproic as been shown to be effective in people who have taken opioid pain medicines (for at least 4 weeks) to treat chronic pain that is not caused by cancer. You should not use Symproic if you have a blockage in your stomach or intestines. Learn more

Symproic Side Effects

Symproic Side Effects

Note: This document contains side effect information about naldemedine. Some of the dosage forms listed on this page may not apply to the brand name Symproic.

For the Consumer

Applies to naldemedine: oral tablet

Along with its needed effects, naldemedine (the active ingredient contained in Symproic) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking naldemedine:

More common

  • Diarrhea
  • nausea
  • stomach pain

Less common

  • Fast heartbeat
  • fever
  • hives, itching, or rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • loss of appetite
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • vomiting
  • weakness

Incidence not known

  • Bloody, black, or tarry stools
  • chills
  • feeling cold
  • heartburn
  • increased sweating
  • indigestion
  • redness on the face, neck, arms, and upper chest
  • severe abdominal or stomach pain, cramping, or burning
  • vomiting of material that looks like coffee grounds, severe and continuous

Some side effects of naldemedine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Fast, pounding, or irregular heartbeat or pulse
  • increased tearing

For Healthcare Professionals

Applies to naldemedine: oral tablet


The most commonly reported adverse reactions have included abdominal pain, diarrhea, nausea and vomiting.


Frequency not reported: Bronchospasm, rash

During clinical trials, 2 patients developed symptoms of hypersensitivity. One had bronchospasm and the other had a rash.


Adverse reactions consistent with opioid withdrawal have been reported. These reactions may have included hyperhidrosis, hot flush or flushing, chills, tremor, tachycardia, anxiety, agitation, yawning, rhinorrhea, increased lacrimation, sneezing, feeling cold, pyrexia, vomiting, diarrhea, or abdominal pain. The incidence of adverse reactions of opioid withdrawal in 2 pooled studies was similar to placebo (8/542 vs 3/546); in a 52-week study the incidence in drug-treated patients was 3% (20/621) versus 1% (9/619) for placebo.

Common (1% to 10%): Opioid withdrawal


Very common (10% or more): Abdominal pain (up to 11%)

Common (1% to 10%): Diarrhea, nausea, gastroenteritis, vomiting

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Symproic