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Supprelin la

Generic Name: Histrelin Implant (CPP) (his TREL in)
Brand Name: Supprelin LA
Easy-to-read patient leaflet for Supprelin LA. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
For all patients taking Supprelin LA (histrelin implant (CPP)): If your child is or may be pregnant: If your child is breast-feeding a baby: This medicine may interact with other drugs or health problems. Tell the doctor and pharmacist about all of your child's drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take Supprelin LA (histrelin implant (CPP)) with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor. Learn more

Supprelin la Side Effects

Supprelin LA Side Effects

Note: This document contains side effect information about histrelin. Some of the dosage forms listed on this page may not apply to the brand name Supprelin LA.

For the Consumer

Applies to histrelin: subcutaneous implant

Along with its needed effects, histrelin (the active ingredient contained in Supprelin LA) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking histrelin:


  • Bloody urine
  • decreased frequency or amount of urine
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • nausea
  • swelling of the face, fingers, or lower legs
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Incidence not known

  • Bloating of the stomach
  • dark urine
  • discouragement
  • feeling sad or empty
  • irritability
  • light-colored stools
  • loss of interest or pleasure
  • seizures
  • stomach pain
  • trouble concentrating
  • trouble sleeping
  • yellow eyes or skin

Some side effects of histrelin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decrease in testicle size
  • feeling of warmth
  • local infection, irritation, pain, redness, or swelling on the skin where the implant was placed
  • redness of the face, neck, arms, and upper chest
  • sudden sweating

Less common

  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement
  • flushing or redness of the skin
  • headache
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • swelling of the breast or breast soreness in both females and males
  • unusually warm skin

For Healthcare Professionals

Applies to histrelin: subcutaneous implant, subcutaneous kit


Common (1% to 10%): Elevated blood glucose, gynecomastia

Uncommon (0.1% to 1%): Elevated blood lactate dehydrogenase, elevated blood testosterone

Rare (less than 0.1%): Benign pituitary tumor

Postmarketing reports: Pituitary apoplexy


Very common (10% or more): Hot flashes (up to 65.5%)

Common (1% to 10%): Blushing

Uncommon (0.1% to 1%): Hematoma, peripheral edema

Rare (less than 0.1%): Palpitations, ventricular extrasystoles


Very common (10% or more): Implant/application site reaction (up to 51.1%)

Common (1% to 10%): Implant/application site injury, keloid scar, scar, suture-related complication, post procedural pain

Postmarketing reports: Implant breakage

Implant/application site reactions includes discomfort, bruising, soreness, pain, tenderness, tingling, itching, erythema, inflammation, protrusion, and swelling.


Common (1% to 10%): Asthenia, fatigue

Uncommon (0.1% to 1%): Sexual dysfunction, breast pain, breast tenderness, pain (exacerbated and non specific), swelling, feeling cold, bruising, malaise

Rare (less than 0.1%): Wound infection, disease progression


Common (1% to 10%): Mood changes, depression, decreased libido, insomnia

Uncommon (0.1% to 1%): Irritability


Common (1% to 10%): Arthralgia, pain in the extremities

Uncommon (0.1% to 1%): Back pain, muscle spasm, muscle infiltration, neck pain, bone pain, muscle twitching, myalgia


Common (1% to 10%): Contusion, hypotrichosis, hypertrichosis

Uncommon (0.1% to 1%): Night sweats, pruritus, hyperhidrosis

Rare (less than 0.1%): Skin infection


Common (1% to 10%): Constipation

Uncommon (0.1% to 1%): Abdominal discomfort, nausea


Common (1% to 10%): Erectile dysfunction, testicular atrophy, pollakisuria, urinary retention

Uncommon (0.1% to 1%): Male genital pruritus, dysuria, hematuria, elevated prostatic acid phosphatase, ureteral stent occlusion, urinary frequency

Rare (less than 0.1%): Dysmenorrhea, menorrhagia, metrorrhagia


Supprelin LA(R):

-The most common adverse reactions involved the implant site, including bruising, pain, soreness, erythema, and swelling.


Uncommon (0.1% to 1%): Anemia


Common (1% to 10%): Hepatic disorder

Uncommon (0.1% to 1%): Elevated aspartate aminotransferase

Postmarketing reports: Drug-induced liver injury


Rare (less than 0.1%): Influenza-like illness


Common (1% to 10%): Fluid retention, hypercalcemia, hypercholesterolemia, food cravings, increased appetite, weight gain, weight loss

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Tremor, lethargy

Rare (less than 0.1%): Migraine

Postmarketing reports: Seizures/convulsions


Common (1% to 10%): Impaired renal function

Uncommon (0.1% to 1%): Renal failure, nephrolithiasis, decreased creatinine clearance


Common (1% to 10%): Exertional dyspnea

Rare (less than 0.1%): Epistaxis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Supprelin La