Commonly reported side effects of sulindac include: increased liver enzymes. See below for a comprehensive list of adverse effects.
Applies to sulindac: oral tablet
Oral route (Tablet)
NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Sulindac is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs may also cause an increased risk of serious gastrointestinal (GI) adverse events, especially in the elderly. These events may include GI bleeding, ulceration, and perforation, which can be fatal.
Along with its needed effects, sulindac may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sulindac:
Get emergency help immediately if any of the following symptoms of overdose occur while taking sulindac:
Symptoms of overdose
Some side effects of sulindac may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to sulindac: compounding powder, oral tablet
The most frequently reported adverse effects were gastrointestinal (GI) in nature and included GI pain, dyspepsia, nausea with or without vomiting, diarrhea, constipation, flatulence, and GI cramps.
Common (1% to 10%): Gastrointestinal (GI) pain, dyspepsia, nausea, vomiting, diarrhea, constipation, flatulence, anorexia, GI cramps
Frequency not reported: Gastritis, gastroenteritis, colitis, peptic ulcer, GI bleeding, GI perforation, intestinal strictures, pancreatitis, glossitis, stomatitis, hematemesis, melena
Common (1% to 10%): Dizziness, headache
Frequency not reported: Ageusia, paresthesia, somnolence, convulsions, syncope, neuritis, drowsiness
Common (1% to 10%): Tinnitus, edema
Frequency not reported: Sore/dry mucous membranes, vertigo, insomnia, aseptic meningitis, hearing decreased, metallic/bitter taste, asthenia, malaise, fatigue
Common (1% to 10%): Nervousness
Frequency not reported: Depression, psychic disturbances, acute psychosis, hallucinations, confusion
Common (1% to 10%): Rash, pruritus
Frequency not reported: Alopecia, photosensitivity, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, ecchymosis, purpura, urticaria, angioneurotic edema, fulminant necrotizing fasciitis, sweating
Frequency not reported: Thrombocytopenia, leukopenia, agranulocytosis, neutropenia, bone marrow depression, aplastic anemia, hemolytic anemia, prothrombin time increased
Frequency not reported: Congestive heart failure, palpitation, hypertension, arrhythmia
Frequency not reported: Anaphylaxis, hypersensitivity vasculitis
A potentially fatal apparent hypersensitivity reaction has been reported. Signs and symptoms of such reaction include constitutional symptoms (e.g., fever, chills, diaphoresis, and flushing), cutaneous reactions (e.g., rash or other dermatologic reactions), conjunctivitis, involvement of major organs (e.g., changes in liver function including hepatic failure, jaundice, pancreatitis, pneumonitis with or without pleural effusion, leukopenia, leukocytosis, eosinophilia, disseminated intravascular coagulation, anemia, renal impairment, including renal failure), and other less specific findings (e.g., adenitis, arthralgia, arthritis, myalgia, fatigue, malaise, hypotension, chest pain, and tachycardia).
Rare cases of metabolites of this drug being found in common bile duct "sludge" and biliary calculi have been reported in patients with symptoms of cholecystitis who underwent a cholecystectomy.
Frequency not reported: Jaundice, cholestasis, hepatitis, hepatic failure, liver function abnormalities
Frequency not reported: Renal impairment, renal failure, interstitial nephritis, nephrotic syndrome, renal calculi
Frequency not reported: Hyperkalemia, hyperglycemia
Frequency not reported: Muscle weakness
Frequency not reported: Urine discoloration, dysuria, vaginal bleeding, hematuria, proteinuria, crystalluria
Frequency not reported: Blurred vision, visual disturbances, disturbance of retina and its vasculature
Frequency not reported: Epistaxis, bronchial spasm, dyspnea
Frequency not reported: Gynecomastia
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Sulindac