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Stromectol

Generic Name: Ivermectin (Systemic) (eye ver MEK tin)
Brand Name: Stromectol
Easy-to-read patient leaflet for Stromectol. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This medicine may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Stromectol (ivermectin (systemic)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Stromectol (ivermectin (systemic)) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Stromectol Side Effects

Stromectol Side Effects

Note: This document contains side effect information about ivermectin. Some of the dosage forms listed on this page may not apply to the brand name Stromectol.

In Summary

Common side effects of Stromectol include: fever, pruritus, and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ivermectin: oral tablet

Along with its needed effects, ivermectin (the active ingredient contained in Stromectol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking ivermectin:

Less common—for the treatment of river blindness (onchocerciasis) only

  • Eye or eyelid irritation, pain, redness, or swelling

Some side effects of ivermectin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common—for the treatment of river blindness (onchocerciasis) only

  • Fever, itching or skin rash
  • joint or muscle pain
  • painful and tender glands in neck, armpits, or groin
  • rapid heartbeat

Less common—for the treatment of river blindness (onchocerciasis) only

  • Headache
  • swelling of the face, hands, arms, feet, or legs

Less common—for the treatment of strongyloidiasis only

  • Diarrhea
  • dizziness
  • skin rash or itching

Rare—for the treatment of river blindness (onchocerciasis) only

  • Lightheadedness when getting up from a lying or sitting position

Rare—for the treatment of strongyloidiasis only

  • Loss of appetite
  • shaking or trembling
  • sleepiness

For Healthcare Professionals

Applies to ivermectin: compounding powder, oral tablet

General

Ivermectin (the active ingredient contained in Stromectol) is well tolerated compared to other microfilaricidal agents (i.e., thiabendazole, diethylcarbamazine). Adverse reactions (i.e., pruritus, fever, rash, myalgia, headache) occur commonly during the first 3 days after treatment and appear to be related to the extent of parasitic infection and systemic mobilization and killing of microfilariae. The majority of reactions can usually be treated with aspirin, acetaminophen and/or antihistamines. Adverse effects tend to occur with lesser frequency during periods of retreatment.

Ocular

Ocular side effects have included eyelid edema, anterior uveitis, blurred vision, conjunctivitis, limbitis, punctate opacity, keratitis, abnormal sensation in the eyes, and chorioretinitis/choroiditis; however, these effects are also associated with the disease onchocerciasis. Loss of vision has occurred rarely but usually resolved without corticosteroid treatment. Conjunctival hemorrhage has been reported during postmarketing experience in patients treated for onchocerciasis.

Other

Worsening of Mazzotti reactions, including arthralgia, synovitis, lymph node enlargement and tenderness, pruritus, skin involvement (including edema, papular and pustular or frank urticarial rash), and fever, has been reported during the first 4 days following treatment for onchocerciasis.

Nervous system

Nervous system side effects have included dizziness, headache, somnolence, vertigo, and tremor. Serious or fatal encephalopathy has been reported rarely in patients with onchocerciases, and heavily infected with Loa loa, either spontaneously or after treatment with ivermectin (the active ingredient contained in Stromectol) Seizures have been reported during postmarketing experience.

Gastrointestinal

Gastrointestinal side effects have included anorexia, constipation, diarrhea, nausea, vomiting, and abdominal distention.

Other

Other side effects have included asthenia, fatigue, abdominal pain, chest discomfort, facial edema, and peripheral edema.

Hematologic

Hematologic side effects have included decreased leukocyte count (3%), eosinophilia (3%), and increased hemoglobin (1%). Hematomatous swellings associated with prolonged prothrombin times have been reported, but the clinical significance is unknown. Leukopenia and anemia have been reported in at least one patient.

Hepatic

Hepatic side effects have included elevated ALT and/or AST. Elevated liver enzymes, elevated bilirubin, and hepatitis have been reported during postmarketing experience.

Cardiovascular

Cardiovascular side effects have included tachycardia and orthostatic hypotension. EKG changes, including prolonged PR interval, flattened T waves and peaked T waves, have been reported in single cases. Hypotension (primarily orthostatic hypotension) has been reported during postmarketing experience.

Dermatologic

Dermatologic side effects have included pruritus, rash, and urticaria. Toxic epidermal necrolysis and Stevens-Johnson syndrome have been reported during postmarketing experience.

Respiratory

Respiratory side effects have included worsening bronchial asthma, laryngeal edema, and dyspnea.

Musculoskeletal

Musculoskeletal side effects have included myalgia.

Renal

Renal side effects have included rare transient proteinuria.

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Stromectol