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Stiolto respimat

Generic Name: olodaterol and tiotropium (OH loe DAT er ol and TYE oh TROE pee um)
Brand Names: Stiolto Respimat
Stiolto Respimat (tiotropium bromide and olodaterol) is used to treat COPD. Includes Stiolto Respimat side effects, interactions and indications.
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Drug Information:
Stiolto Respima containes a combination of olodaterol and tiotropium. Olodaterol is a long-acting bronchodilator. Tiotropium is an anticholinergic. These medications work by relaxing muscles in the airways to improve breathing. Stiolto Respimat is used to prevent airflow obstruction and reduce flare-ups in adults with COPD (chronic obstructive pulmonary disease), including bronchitis and emphysema. Stiolto Respimat will not treat a bronchospasm attack that has already begun. Stiolto Respimat is for use only in people with COPD and should not be used to treat asthma. Learn more

Stiolto respimat Side Effects

Stiolto Respimat Side Effects

Note: This document contains side effect information about olodaterol / tiotropium. Some of the dosage forms listed on this page may not apply to the brand name Stiolto Respimat.

For the Consumer

Applies to olodaterol/tiotropium: inhalation spray

Warning

Inhalation route (Spray)

Use of long-acting beta 2-adrenergic agonists (LABAs), including olodaterol, increases the risk of asthma-related death. A large, placebo-controlled study showed an increase in asthma-related deaths in patients taking salmeterol added to usual asthma therapy. This finding is considered a class effect of LABAs, including olodaterol. The safety and efficacy of tiotropium bromide/olodaterol in patients with asthma have not been established. Tiotropium bromide/olodaterol is not indicated for the treatment of asthma.

Along with its needed effects, olodaterol / tiotropium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olodaterol / tiotropium:

More common

  • Chest pain
  • chills
  • cough
  • fever
  • sneezing
  • sore throat
  • troubled breathing
  • tightness in the chest

Less common

  • Bladder pain
  • blindness
  • bloody or cloudy urine
  • blurred vision
  • confusion
  • decrease in the frequency of urination
  • decrease in urine volume
  • decreased urination
  • decreased vision
  • difficult, burning, or painful urination
  • difficulty in passing urine (dribbling)
  • dizziness
  • dry mouth
  • eye pain or discomfort
  • fainting
  • fast or irregular heartbeat
  • frequent urge to urinate
  • headache
  • hives, itching, or rash
  • hoarseness
  • increase in heart rate
  • irritation
  • joint pain, stiffness, or swelling
  • lightheadedness
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • lower back or side pain
  • nausea
  • nervousness
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid breathing
  • redness of the skin
  • slow or fast heartbeat
  • sunken eyes
  • swelling of the eyelids, face, lips, hands, or feet
  • tearing
  • thirst
  • troubled swallowing
  • unusual tiredness or weakness
  • visual halos or colored images
  • vomiting
  • wrinkled skin

Some side effects of olodaterol / tiotropium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

  • Back pain
  • bleeding gums
  • bloody nose
  • creamy white, curd-like patches in the mouth or throat
  • difficulty having a bowel movement
  • difficulty with moving
  • dry skin
  • heartburn
  • irritation in the mouth
  • mouth ulcers
  • muscle pain or stiffness
  • pain in the joints
  • pain or tenderness around the eyes and cheekbones
  • pain when eating or swallowing
  • redness and swelling of the gums
  • redness, swelling, or soreness of the tongue
  • stuffy or runny nose
  • swelling or inflammation of the mouth
  • trouble sleeping
  • voice changes

For Healthcare Professionals

Applies to olodaterol / tiotropium: inhalation aerosol

General

The most common serious adverse reactions were COPD exacerbation and pneumonia.

Respiratory

Common (1% to 10%): Nasopharyngitis, cough, epistaxis, pharyngitis, dysphonia, bronchospasm, laryngitis, sinusitis

Cardiovascular

Common (1% to 10%): Atrial fibrillation, palpitations, supraventricular tachycardia

Dermatologic

Common (1% to 10%): Rash, pruritus, angioneurotic edema, urticaria, skin infection, and skin ulcer, dry skin

Gastrointestinal

Common (1% to 10%): Dry mouth, constipation, oropharyngeal candidiasis, dysphagia, gastroesophageal reflux disease, gingivitis, glossitis, stomatitis, intestinal obstruction including ileus paralytic

Genitourinary

Common (1% to 10%): Urinary retention, dysuria, urinary tract infection

Hypersensitivity

Common (1% to 10%): Immediate hypersensitivity reactions

Metabolic

Common (1% to 10%): Dehydration

Musculoskeletal

Common (1% to 10%): Back pain, arthralgia, joint swelling

Nervous system

Common (1% to 10%): Dizziness, insomnia

Ocular

Common (1% to 10%): Glaucoma, increased intraocular pressure, blurred vision

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Stiolto Respimat