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Stay awake

Generic Name: caffeine (Oral route)
Detailed drug Information for Stay Awake. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
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Drug Information:
In the U.S. Available Dosage Forms: Therapeutic Class: CNS Stimulant Chemical Class: Methylxanthine Caffeine tablets are used as an alertness aid to help you keep awake when you experience drowsiness or unusual tiredness or weakness. Do not use this medicine as substitute for sleep. Caffeine oral solution is used to treat short-term apnea of prematurity when premature babies (infants between 28 and 32 weeks gestational age) stop breathing. Apnea of prematurity is caused by the baby's breathing centers not being fully developed. Learn more

Stay awake Side Effects

Stay Awake Side Effects

Note: This document contains side effect information about caffeine. Some of the dosage forms listed on this page may not apply to the brand name Stay Awake.

For the Consumer

Applies to caffeine: oral solution, oral tablet

Other dosage forms:

  • intravenous solution

Along with its needed effects, caffeine (the active ingredient contained in Stay Awake) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking caffeine:

More common

  • Feeding intolerance

Less common

  • Agitation
  • black, tarry stools
  • blood in the stools or urine
  • bruising
  • burning feeling or tenderness in the stomach
  • chills
  • coma
  • confusion
  • coughing or vomiting blood
  • decreased urine output
  • depression
  • dizziness
  • fainting
  • fast heartbeat
  • fever
  • headache
  • hostility
  • indigestion
  • irritability
  • lethargy
  • lightheadedness
  • muscle twitching
  • nausea
  • persistent bleeding
  • rapid, shallow breathing
  • rapid weight gain
  • rash
  • seizures
  • severe stomach pain
  • stomach upset
  • stupor
  • swelling of the face, ankles, or hands
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting
  • vomiting of blood or material that looks like coffee grounds

Get emergency help immediately if any of the following symptoms of overdose occur while taking caffeine:

Symptoms of overdose

  • Irritability
  • nervousness
  • rapid heartbeat
  • trouble sleeping

Some side effects of caffeine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Rash

Less common

  • Dry skin

For Healthcare Professionals

Applies to caffeine: compounding powder, intravenous solution, oral gum, oral liquid, oral tablet, oral tablet dispersible, oral tablet extended release


Very common (10% or more): Constipation (up to 17.4%)

Common (1% to 10%): Necrotizing enterocolitis, gastritis, GI hemorrhage, gastroesophageal reflux, dilated bowel loops

Frequency not reported: Increased gastric aspirate, GI intolerance, vomiting, regurgitation


Long-term follow-up studies have not shown caffeine (the active ingredient contained in Stay Awake) to adversely affect neurological development or growth parameters.


Common (1% to 10%): Hemorrhage, tachycardia

Uncommon (0.1% to 1%): Arrhythmia

Frequency not reported: Increased left ventricular output, increased stroke volume, hypertension


Common (1% to 10%): Rash, dry skin, skin breakdown


Common (1% to 10%): Disseminated intravascular coagulation, anemia

Frequency not reported: Decreased hemoglobin


Common (1% to 10%): Kidney failure


Common (1% to 10%): Acidosis, hyperglycemia

Frequency not reported: Hypoglycemia, temporary reduced weight gain, decreased thyroxine

Nervous system

Common (1% to 10%): Cerebral hemorrhage

Uncommon (0.1% to 1%): Convulsions/seizures

Frequency not reported: Irritability, restlessness, jitteriness, tremors, brain injury


Common (1% to 10%): Retinopathy of prematurity


Common (1% to 10%): Perinatal disorder (trace aspirates, feeding intolerances), injection site reaction, sepsis, accidental injury, abnormal healing, infusion site phlebitis and inflammation

Frequency not reported: Failure to thrive, deafness


Common (1% to 10%): Dyspnea, lung edema

Frequency not reported: Tachypnea


Rare (less than 0.1%): Hypersensitivity reaction


Frequency not reported: Increased urine flow rate, increased creatinine clearance, increased sodium and calcium excretion

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Stay Awake