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Generic Name: pegvisomant (peg VIH so mant)
Brand Names: Somavert
Somavert is used to treat acromegaly, a growth disorder caused by too much growth hormone. Learn about side effects, interactions and indications.
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Drug Information:
Somavert (pegvisomant) is a man-made protein that is similar to human growth hormone. Pegvisomant binds to the same receptor in the body as growth hormone, and blocks the effects of growth hormone. Somavert is used to treat acromegaly (a growth disorder caused by too much growth hormone). Somavert is usually given after other medications, surgery, or radiation have been tried without successful treatment of symptoms. You should not use Somavert if you are allergic to pegvisomant. Before using Somavert, tell your doctor if you have diabetes, liver disease, a latex allergy, or a tumor that secretes growth hormone. Learn more

Somavert Side Effects

Somavert Side Effects

Note: This document contains side effect information about pegvisomant. Some of the dosage forms listed on this page may not apply to the brand name Somavert.

For the Consumer

Applies to pegvisomant: subcutaneous powder for solution

Along with its needed effects, pegvisomant (the active ingredient contained in Somavert) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pegvisomant:

More common

  • Bleeding, blistering, burning, coldness, or discoloration of skin at site of injection
  • bloating or swelling of face, arms, hands, lower legs, or feet
  • blurred vision
  • chest pain
  • chills
  • cough
  • dizziness
  • feeling of pressure
  • fever
  • headache
  • hives
  • hoarseness
  • infection, inflammation, itching, or lump at site of injection
  • nervousness
  • lower back or side pain
  • painful or difficult urination
  • pounding in the ears
  • rapid weight gain
  • slow or fast heartbeat
  • tingling of hands or feet
  • unusual weight gain or loss

Less common

  • Thickening of the skin

Incidence not known

  • Abdominal pain or tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • fever
  • itching
  • loss of appetite
  • nausea and vomiting
  • skin rash
  • unusual tiredness or weakness
  • yellow eyes or skin

Some side effects of pegvisomant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Accidental injury
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • general feeling of discomfort or illness
  • joint pain
  • muscle aches and pains
  • pain
  • pain or tenderness around eyes and cheekbones
  • runny or stuffy nose
  • shivering
  • shortness of breath or troubled breathing
  • sore throat
  • sweating
  • tightness of chest or wheezing
  • trouble sleeping

For Healthcare Professionals

Applies to pegvisomant: subcutaneous powder for injection


Frequency not reported: Liver test elevations


Frequency not reported: Hypoglycemia in patients with diabetes mellitus


Frequency not reported: Lipohypertrophy


Frequency not reported: Cross-reactivity with growth hormone assay


Frequency not reported: Systemic hypersensitivity

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Somavert