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Somatuline depot

Generic Name: lanreotide (lan REE oh tide)
Brand Names: Somatuline Depot
Somatuline Depot is used as a long-term treatment for acromegaly. Learn about side effects, interactions and indications.
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Drug Information:
Somatuline Depot (lanreotide) is a man-made protein similar to a hormone in the body called somatostatin. Lanreotide lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), growth hormone, and chemicals that affect digestion. Somatuline Depo is used in adults to treat: acromegaly that cannot be treated with surgery or radiation; carcinoid syndrome; or a certain type of pancreatic or digestive tract tumor that may spread to other parts of the body. Somatuline Depo is sometimes given after other treatments have failed. Learn more

Somatuline depot Side Effects

Somatuline Depot Side Effects

Note: This document contains side effect information about lanreotide. Some of the dosage forms listed on this page may not apply to the brand name Somatuline Depot.

In Summary

Common side effects of Somatuline Depot include: diarrhea. Other side effects include: cholelithiasis, hypertension, and sinus bradycardia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lanreotide: subcutaneous solution

Along with its needed effects, lanreotide (the active ingredient contained in Somatuline Depot) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lanreotide:

More common

  • Blurred vision
  • chest pain or discomfort
  • dizziness
  • gaseous abdominal or stomach pain
  • headache
  • lightheadedness, dizziness, or fainting
  • nervousness
  • pale skin
  • pounding in the ears
  • recurrent fever
  • slow, fast, or irregular heartbeat
  • stomach fullness
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

Incidence not known

  • Bloating
  • chills
  • constipation
  • cough
  • dark urine
  • diarrhea
  • difficulty swallowing
  • fast heartbeat
  • fat in the stool
  • fever
  • hives, itching, skin rash
  • indigestion
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • nausea
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe nausea or vomiting
  • stomach pain or cramps
  • sudden loss of weight
  • tightness in the chest
  • vomiting

Some side effects of lanreotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement
  • difficulty with moving
  • excess air or gas in the stomach or intestines
  • feeling of fullness
  • inflammation, itching, lumps, or pain at the injection site
  • muscle pain or stiffness
  • pain in the joints
  • passing gas
  • weight loss

For Healthcare Professionals

Applies to lanreotide: subcutaneous solution


The most common adverse events were gastrointestinal disorders, cholelithiasis, and injection site reactions.


In one of the studies, diarrhea, abdominal pain, and flatulence increased as the dose increased.

Very common (10% or more): Diarrhea (up to 65%), abdominal pain (34%), vomiting (19%), flatulence (14%), nausea (11%), loose stools

Common (1% to 10%): Constipation, flatulence, abdominal distension, abdominal discomfort, dyspepsia

Uncommon (0.1% to 1%): Pancreatitis, feces discolored

Frequency not reported: Steatorrhea


Very common (10% or more): Cholelithiasis (27%), bladder sludge (20%), new cholelithiasis

Common (1% to 10%): ALT increased, AST abnormal, ALT abnormal, blood bilirubin increased, biliary dilatation

Uncommon (0.1% to 1%): AST increased, blood alkaline phosphatase increased, blood bilirubin abnormal

Frequency not reported: Cholecystitis

Postmarketing reports: Steatorrhea, pancreatitis


Very common (10% or more): Bradycardia (18%), hypertension (14%)

Common (1% to 10%): Sinus bradycardia

Uncommon (0.1% to 1%): Other cardiac adverse drug reactions


Very common (10% or more): Application site disorder (injection site mass/pain/reaction/inflammation/ nodule/pruritus, 30%)

Postmarketing reports: Persisting induration, injection site abscess


Very common (10% or more): Dysglycemia (hypoglycemia, hyperglycemia, diabetes, 14%), weight decrease (11%)

Common (1% to 10%): Blood glucose increased, glycosylated hemoglobin increased

Uncommon (0.1% to 1%): Blood sodium decreased, diabetes mellitus aggravated


Very common (10% or more): Anemia (14%)


Very common (10% or more): Musculoskeletal pain (19%), arthralgia (11%)

Nervous system

Very common (10% or more): Headache (16%)

Common (1% to 10%): Dizziness

Postmarketing reports: Dysautonomia


Common (1% to 10%): Dyspnea


Common (1% to 10%): Depression

Uncommon (0.1% to 1%): Insomnia


Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Hot flush, asthenia

Postmarketing reports: Malaise


Common (1% to 10%): Anti-lanreotide (the active ingredient contained in Somatuline Depot) antibodies


Frequency not reported: Allergic reactions (including angioedema, anaphylaxis, and hypersensitivity)


Common (1% to 10%): Alopecia, hypotrichosis


Rare (less than 0.1%): Clinical hypothyroidism

Frequency not reported: Slight decreases in thyroid function

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Somatuline Depot