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Generic Name: brodalumab (broe DAL ue mab)
Brand Names: Siliq
Siliq (brodalumab) is a monoclonal antibody that blocks certain proteins in the body that can affect inflammation and other immune responses. Siliq is used to treat moderate to severe plaque psoriasis in adults. Includes side effects, interactions and indications.
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Drug Information:
Siliq (brodalumab) is a monoclonal antibody that blocks certain proteins in the body that can affect inflammation and other immune responses. Siliq is used to treat moderate to severe plaque psoriasis in adults. It is usually given after other psoriasis medicines have been tried without success. Siliq is available only from a certified pharmacy under a special program called Siliq REMS. You must be registered in the program and understand the risks and benefits of taking this medicine. Some people have thoughts about suicide while taking Siliq. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as mood changes, anxiety, or depression. Learn more

Siliq Side Effects

Siliq Side Effects

Note: This document contains side effect information about brodalumab. Some of the dosage forms listed on this page may not apply to the brand name Siliq.

In Summary

Common side effects of Siliq include: infection. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to brodalumab: subcutaneous solution


Subcutaneous route (Solution)

Suicidal ideation and behavior, including completed suicides, have occurred with brodalumab. Weigh potential risks and benefits in each patient prior to initiation, and advise patients and caregivers to seek medical attention for new or worsening depression, anxiety, or other mood changes. Refer patients with new or worsening suicidal ideation and behavior to a mental health professional. Brodalumab is only available through a restricted program called the Siliq REMS Program.

Along with its needed effects, brodalumab (the active ingredient contained in Siliq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brodalumab:

Less common

  • Black, tarry stools
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • painful or difficult urination
  • pale skin
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • thoughts of killing oneself
  • trouble concentrating
  • trouble sleeping

Some side effects of brodalumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Difficulty with moving
  • muscle pain or stiffness
  • pain in the joints
  • pain, redness, burning, or itching at the injection site

For Healthcare Professionals

Applies to brodalumab: subcutaneous solution


Common (1% to 10%): Diarrhea, oropharyngeal pain, nausea


Common (1% to 10%): Neutropenia


Frequency not reported: Urinary tract infection


Common (1% to 10%): Fatigue


Common (1% to 10%): Influenza, tinea infections (i.e., tinea pedis, tinea versicolor, tinea cruris), immunogenicity

Uncommon (0.1% to 1%): Candida infections (i.e., oral, genital, esophageal)


Common (1% to 10%): Injection site reactions (i.e., pain, erythema, bruising, hemorrhage, pruritus)


Common (1% to 10%): Arthralgia, myalgia

Nervous system

Common (1% to 10%): Headache


Uncommon (0.1% to 1%): Conjunctivitis


Frequency not reported: Nasopharyngitis, upper respiratory tract infection, pharyngitis, bronchitis


Uncommon (0.1% to 1%): Suicidal ideation or behavior

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Siliq