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Generic Name: romidepsin (ROE mi DEP sin)
Brand Name: Istodax
Physician reviewed romidepsin patient information - includes romidepsin description, dosage and directions.
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Drug Information:
Romidepsin is used to treat T-cell lymphoma affecting the skin (cutaneous T-cell lymphoma, or peripheral T-cell lymphoma). Romidepsin is given after at least one other cancer treatment did not work or has stopped working. Romidepsin may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. You should not use romidepsin if you are allergic to it. Learn more

Romidepsin Side Effects

Romidepsin Side Effects

For the Consumer

Applies to romidepsin: intravenous powder for solution

Along with its needed effects, romidepsin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking romidepsin:

More common

  • Abdominal or stomach cramps or pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • bone pain
  • chest pain
  • chills
  • confusion
  • convulsions
  • cough or hoarseness
  • decreased urine output
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fast or irregular heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • joint pain, stiffness, or swelling
  • loss of appetite
  • lower back or side pain
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle spasms or twitching
  • nausea or vomiting
  • numbness or tingling in the hands, fingertips, feet, or lips
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • seizures
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sweating
  • swelling of the face, ankles, feet, lower legs, or hands
  • swollen glands
  • tremor
  • troubled breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of romidepsin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change in taste
  • constipation
  • cracks in the skin
  • diarrhea
  • itching
  • lack or loss of strength
  • loss of appetite
  • loss of heat from the body
  • loss of taste
  • red, swollen skin
  • scaly skin
  • weight loss

For Healthcare Professionals

Applies to romidepsin: intravenous powder for injection


Very common (10% or more): Nausea (up to 86%), vomiting (up to 52%), constipation (up to 40%), diarrhea (up to 36%), abdominal pain (up to 14%)

Common (1% to 10%): Stomatitis


The most commonly reported adverse events included neutropenia, lymphopenia, thrombocytopenia, infections, nausea, fatigue, vomiting, anorexia, anemia, and ECG T-wave changes.

The most commonly reported events leading to discontinuation included infection, fatigue, dyspnea, QT prolongation, and hypomagnesemia.


Very common (10% or more): Anemia (up to 72%), neutropenia (up to 66%), leukopenia (up to 46%), thrombocytopenia (up to 65%), lymphopenia (up to 57%)


Very common (10% or more): ST-T wave changes on ECG (up to 63%); Hypotension (up to 23%)

Common (1% to 10%): Tachycardia, supraventricular arrhythmia, ventricular arrhythmia, edema, deep vein thrombosis, chest pain

Frequency not reported: QT prolongation


Very common (10% or more): Anorexia (up to 54%), hypocalcemia (up to 52%), hyperglycemia (up to 51%), hypoalbuminemia (up to 48%), hyperuricemia (up to 33%), hypomagnesemia (up to 28%), hypermagnesemia (up to 27%), hypophosphatemia (up to 27%), hypokalemia (up to 20%), weight loss (up to 15%), hyponatremia (up to 20%),

Common (1% to 10%): Dehydration, hypoalbuminemia, hyperuricemia, tumor lysis syndrome

Nervous system

Very common (10% or more): Dysgeusia (up to 40%), headache (up to 34%)

Common (1% to 10%): Syncope, dizziness


Very common (10% or more): AST elevations (up to 28%), ALT elevations (up to 22%)

Common (1% to 10%): Hyperbilirubinemia


Very common (10% or more): Pruritus (up to 31%), dermatitis/exfoliative dermatitis (up to 27%)

Common (1% to 10%): Rash


Common (1% to 10%): Hypersensitivity


Very common (10% or more): Infections (up to 54%)

Common (1% to 10%): Sepsis, upper respiratory infection, urinary tract infection, pneumonia, cellulitis, oral candidiasis, central line infection, catheter related infection


Very common (10% or more): Asthenia/fatigue (up to 77%), pyrexia (up to 47%), chills (up to 17%)

Common (1% to 10%): Febrile neutropenia


Very common (10% or more): Cough (up to 21%), dyspnea (up to 21%)

Common (1% to 10%): Pulmonary embolism, pneumonitis


Common (1% to 10%): Muscle spasms, myalgia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Romidepsin