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Generic Name: oxymetazoline topical (OX ee me TAZ o leen TOP i kal)
Brand Names: Rhofade
Rhofade (oxymetazoline hydrochloride) cream is used to treat facial erythema (redness) associated with rosacea. Includes Rhofade side effects, interactions and indications.
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Drug Information:
Rhofade (oxymetazoline) is a decongestant that shrinks blood vessels. Dilated blood vessels under the skin can cause redness. Rhofade is used to treat facial redness caused by rosacea. Rhofade may also be used for purposes not listed in this medication guide. Do not take Rhofade by mouth. Topical medicine is for use only on the skin. Rinse with water if this medicine gets in your eyes. You should not use Rhofade if you are allergic to oxymetazoline. To make sure Rhofade is safe for you, tell your doctor if you have: Learn more

Rhofade Side Effects

Rhofade Side Effects

Note: This document contains side effect information about oxymetazoline topical. Some of the dosage forms listed on this page may not apply to the brand name Rhofade.

For the Consumer

Applies to oxymetazoline topical: topical application cream

Along with its needed effects, oxymetazoline topical (the active ingredient contained in Rhofade) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxymetazoline topical:

Less common

  • Blistering, crusting, irritation, itching, or reddening of the skin
  • cracked, dry, scaly skin
  • swelling or pain at the application site
  • worsening of rosacea pimples

For Healthcare Professionals

Applies to oxymetazoline topical: topical cream


Common (1% to 10%): Application site dermatitis/pruritus/pain

Uncommon (0.1% to 1%): Application site erythema


Common (1% to 10%): Worsening inflammatory lesions of rosacea

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Rhofade