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Generic Name: Pyridostigmine Injection (peer id oh STIG meen)
Brand Name: Regonol
Easy-to-read patient leaflet for Regonol. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This is not a list of all drugs or health problems that interact with Regonol (pyridostigmine injection). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Regonol (pyridostigmine injection) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Regonol (pyridostigmine injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Regonol Side Effects

Regonol Side Effects

Note: This document contains side effect information about pyridostigmine. Some of the dosage forms listed on this page may not apply to the brand name Regonol.

For the Consumer

Applies to pyridostigmine: oral conventional 30-mg tablets for military use, oral conventional 60-mg tablets and extended-release tablets, oral oral solution, parenteral injection


    Military Use for Soman Poisoning Prophylaxis
  • Use of pyridostigmine alone is not protective against soman effects. Efficacy depends on rapid use of nerve agent antidotes (i.e., atropine and pralidoxime) following nerve agent exposure.

  • Protective garments (e.g., masks, hoods, overgarments) specifically designed for protection from chemical nerve agents are the primary means of protection against nerve agent exposure; do not rely solely on pretreatment with pyridostigmine, atropine, and pralidoxime to provide complete protection.

  • Do not administer pyridostigmine after soman exposure. Discontinue at first sign of nerve agent poisoning; may exacerbate effects of a sublethal exposure.

    Experience of Health Care Personnel
  • Pyridostigmine should be administered by IV injection only by adequately trained individuals familiar with the drug’s actions, characteristics, and risks.

Side effects include:

Diarrhea, abdominal pain or cramps, dysmenorrhea, increased flatus, nausea, urinary urgency and frequency.

For Healthcare Professionals

Applies to pyridostigmine: injectable solution, oral syrup, oral tablet, oral tablet extended release


Frequency not reported: Nausea, vomiting, diarrhea, abdominal cramps, GI hypermotility, salivary hypersecretion


Frequency not reported: Increased bronchial secretion combined with bronchoconstriction


Frequency not reported: Muscle weakness, fasciculation, tremors, muscle cramps, muscle hypotonia


Frequency not reported: Miosis, increased lacrimation, accommodation disorders


Frequency not reported: Rash, hyperhidrosis


Frequency not reported: Arrhythmia (including bradycardia, tachycardia, AV block), syncope, hypotension


Frequency not reported: Urinary urgency

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Regonol