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Generic Name: glycerol phenylbutyrate (GLIS er ol FEN il BUE ti rate)
Brand Names: Ravicti
Ravicti (glycerol phenylbutyrate) is used to treat urea cycle disorders. Includes Ravicti side effects, interactions and indications.
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Drug Information:
Ravicti (glycerol phenylbutyrate) binds with other substances in the liver and kidneys to help eliminate nitrogen from the body. Excess nitrogen can cause hyperammonemia, a build-up of ammonia in the blood. Ammonia is very toxic when it circulates in blood and tissues and can cause permanent brain damage, coma, or death. Ravicti helps prevent a build-up of ammonia in the blood in people with urea cycle disorder. This medicine is used in adults, children and infants. Ravicti will not treat hyperammonemia. Learn more

Ravicti Side Effects

Ravicti Side Effects

Note: This document contains side effect information about glycerol phenylbutyrate. Some of the dosage forms listed on this page may not apply to the brand name Ravicti.

In Summary

Common side effects of Ravicti include: dizziness, fatigue, headache, nausea, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to glycerol phenylbutyrate: oral solution

Along with its needed effects, glycerol phenylbutyrate (the active ingredient contained in Ravicti) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glycerol phenylbutyrate:

More common

  • Continuing nausea or vomiting
  • increase in the frequency of seizures
  • loss of appetite
  • swelling of the face
  • tiredness and weakness

Some side effects of glycerol phenylbutyrate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloated or full feeling
  • diarrhea
  • excess air or gas in the stomach or intestines
  • headache
  • nausea
  • passing gas
  • rash
  • upper abdominal or stomach pain
  • vomiting

Less common

  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • stomach discomfort or upset

For Healthcare Professionals

Applies to glycerol phenylbutyrate: oral liquid


The most frequently reported side effects included diarrhea, flatulence, and headache.

Nervous system

Very common (10% or more): Headache (14%), dizziness


Very common (10% or more): Diarrhea (16%), flatulence (14%), upper abdominal pain (pediatric patients), nausea , vomiting

Common (1% to 10%): Abdominal pain (adults) dyspepsia


Very Common (10% or more): Decreased appetite, hyperammonemia


Common (1% to 10%): Fatigue


Very common (10% or more): Rash (pediatric patients)

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Ravicti